Open fractures account for approximately 20% of all combat-related injuries in soldiers. Because of the severity of wounding mechanisms and high rates of wound infection, open fractures from combat pose greater problems to surgeons and result in higher morbidity than similar injuries suffered by civilians. Standard care for open fractures requires multiple procedures, including irrigation, débr...

INTRODUCTION: Tissue expander(TE) and implant infection is the most common cause of surgical readmission following breast reconstruction. The goals of this study are (1) to characterize a cohort of patients who were treated with IV antibiotics for suspected infection after prosthetic breast reconstruction, (2) to identify local microbiome and (3) elucidate an optimal antibiotic treatment protoc...

Infection is a common complication in open fractures that compromises the healing of bone and can result in loss of limb or life. Currently, the clinical standard of care for treating contaminated open fractures comprises a staged approach, wherein the wound is first treated with non-biodegradable antibiotic-laden poly(methyl methacrylate) (PMMA) beads to control the infection followed by bone ...

Background and purpose - Antibiotic treatment of patients before specimen collection reduces the ability to detect organisms by culture. We investigated the suppressive effect of antibiotics on the growth of non-adherent, planktonic, and surface-related biofilm bacteria in vitro by using sonication and microcalorimetry methods. Patients and methods - Biofilms of Staphylococcus aureus, S. epider...

The ability of trovafloxacin and ciprofloxacin to select efflux mutants in vivo was studied in a model of acute Pseudomonas aeruginosa pneumonia in rats. Twelve hours after intratracheal inoculation of 10(6) CFU of P. aeruginosa strain PAO1 enmeshed in agar beads, two groups of 12 rats were treated by three intraperitoneal injections of each antibiotic given every 5 h. Dosing regimens were chos...