Abstract: Non-steroidal Anti-inflammatory Drugs (NSAIDs) are the drugs which commonly prescribed and consumed by worldwide. NSAIDs several having high risk of inducing SJS or TEN. TEN cutaneous reactions involves in detachment mucosal skin membrane. Female were more affected than male. Major cause genetic (HLA –A HLA- B), drugs, infection (mycoplasma pneumonia herpes simplex virus). The exact p...

Stereoisomers of the monoterpene epoxycarvone (EC), namely (+)-cis-EC, (-)-cis-EC, (+)-trans-EC, and (-)-trans-EC, were comparatively evaluated for anticonvulsant activity in specific methodologies. In the pentylenetetrazole (PTZ)-induced anticonvulsant test, all of the stereoisomers (at 300 mg/kg) increased the latency to seizure onset, and afforded 100% protection against the death of the ani...

The pharmacokinetics and time course of action of vecuronium in normal children and children receiving anticonvulsant drugs for prolonged periods were characterized. A bolus dose of vecuronium 0.15 mg kg(-1) was administered i.v. to 10 non-epileptic children and to 10 children on phenytoin and 10 children on carbamazepine, who were matched for age and weight. Plasma concentrations of vecuronium...

In conclusion, NMDA antagonists as anticonvulsants are especially active in preventing the generalization of the behavioural and electrical seizures and display a typical spectrum of in vitro antiepileptiform activities. In addition, based on in vitro and in vivo limbic kindled studies, the drugs should be regarded more as an antiepileptiform than as an anticonvulsant drugs. As neuroprotective ...

To simulate a convulsive syndrome, phenylcarbamate was administered intraperitoneally at dose of 1 mg/kg. Valproic acid aminoester (43 mg/kg), caramiphene (50 and diferidine (2 mg/kg) were investigated as potential anticonvulsant drugs. Blood brain tissue for the determination acetylcholinesterase (AСhE) taken 10, 30, 60 minutes, 6 24 hours after administration xenobiotic. In case poisoning wit...