(1971), Hypomania and mania after withdrawal of tricyclic antidepressants. Short and Long term administration of tri-cyclic antidepressants and Lithium on nore-pinephrine turn over in the brain, Science, 199, 197. The honesty of Kramer was dubious. He used to torture witches in Tyrol and was expelled by the local Bishop. Kramer could win a sympathetic hearing by Pope Innocent VIII. The Bull was...

Central neuropathic pain in patients with multiple sclerosis (MS) is a common debilitating symptom, which is mostly treated with tricyclic antidepressants or antiepileptics. Unfortunately, the use of these drugs is often limited due to adverse events. We investigated the analgesic effect of topical amitriptyline 5% and 10% cream in a patient with central neuropathic pain due to MS. The analgesi...

OBJECTIVE To compare the effects and side effects of low dosage tricyclic antidepressants with placebo and with standard dosage tricyclics in acute phase treatment of depression. DESIGN Systematic review of randomised trials comparing low dosage tricyclics (< or =100 mg/day) with placebo or with standard dosage tricyclics in adults with depression. MAIN OUTCOME MEASURES Relative risk of res...

Despite recent advances in understanding the pathophysiology and treatment of migraine, considerable uncertainty remains surrounding the diagnosis and treatment of this disorder. This uncertainty is reflected in studies that show both underdiagnosis and undertreatment of migraine. While the diagnosis can be assisted by criteria from the International Headache Society, other approaches may be us...

Mania due to tricyclic antidepressant use has been well reported in literature but reports of SSRI's induced mania are less. This case reports a sertraline induced mania and discusses the use of this drug in adolescent females.

The aim of the study was to detect the changes of QT dispersion (QTd) due to cardiotoxicity of tricyclic antidepressant dosulepin. Electrocardiographic and vectorcardiographic recordings were obtained using Cardiag 112.2 diagnostic system from 28 psychiatric outpatients treated with prophylactic doses of dosulepin and compared to those obtained from 37 healthy volunteers. From these recordings ...

In seven mongrel dogs the syndrome of depression was evoked by bilateral electrolytic lesions in lateral hypothalamus and/or dorsomedial amygdala. The effects of tricyclic antidepressants on general mood, spinal reflexes recorded by electromyographic method, and head rate were tested. The reactivity to most external stimuli was increased and general depression was slightly reduced.

Empirical evidence regarding the association between antidepressants and valvular heart disease (VHD) is scarce.Using Taiwan's National Health Insurance Research database, this nested case-control study assessed the association between antidepressants and VHD in a Chinese population.Among a cohort of patients who used at least 3 prescription antidepressants, 874 cases with VHD and 3496 matched ...

The explanations for the emergence of cryptogenic fibrosing alveolitis as a new clinical entity during the second half of the 20th century are unclear. The authors have previously reported evidence of an increased risk of cryptogenic fibrosing alveolitis in relation to the use of antidepressant drugs. The authors have now tested this hypothesis a priori in an analysis of computerized general pr...