Hyponatremia (defined as a serum sodium level ! 134 mmol/L) is the most common electrolyte abnormality in hospitalized patients. Certain drugs (eg, diuretics, antidepressants, and antiepileptics) have been implicated as established causes of either asymptomatic or symptomatic hyponatremia. However, hyponatremia occasionally may develop in the course of treatment with drugs used in everyday clin...

Though the authors have excluded patients with known parathyroid disease, rickets, renal tubular acidosis, chronic kidney disease or a diagnosis of acute kidney injury at admission, about 56% children were stated to have some underlying chronic illness. One would be really interested to know the nature of these chronic illnesses, as many diseases such as chronic liver disease [2] and nephrotic ...

A 6-year-old 12 kg male neutered mixed breed dog presented in lateral recumbency with dysphoria and vocalization following a self-inflicted fork impalement injury. Computed tomography (CT) was performed which showed penetrating wound through the right orbit, into calvarium, brain parenchyma. The hospitalized supportive care, sedatives, analgesia, antiepileptics, anti-inflammatories, antibiotics...

Introduction Subacute sclerosing panencephalitis (SSPE) is a serious, late complication of measles, and the prognosis remains poor in absence effective treatment, underscoring role vaccination its prevention. Objectives We describe clinicobiological evolutionary profile 16 patients recruited from B chu de Constantine pediatric department. Patients methods Study of16 cases: epidemiological, clin...

Newly diagnosed epileptic patients start their medication with monotherapy. Around 30% of epileptic patients require more than one antiepileptic drug. Results from experimental studies provide evidence that administration of two antiepileptic drugs may result in antagonistic, additive, or supra-additive (synergistic) anticonvulsant effects. If adverse effects of a synergistic combination also s...

Magnetic stimulation of brain and spinal roots provides a non-invasive evaluation of nervous propagation as well as of motor cortex excitability in healthy subjects and in patients affected by neurological diseases (i.e. multiple sclerosis, stroke, Parkinson's disease, myelopathies etc.). Motor areas can be reliably mapped and short- and long-term 'plastic' changes of neural connections can be ...

In epileptic patients, neurobehavioral problems such as cognitive impairment, depression, and psychosocial impairments have been described, which may have a pathological and/or iatrogenic basis. For this reason additional treatment is required, beside antiepileptic drug (AED) therapy, to correct the accompanying neurological deficits. However, the rationale behind use of antidepressants along w...

OBJECTIVES There are patients with neuropathic pain in whom the treatment is ineffective, despite the fact that is conducted with adherence to the current guidelines. In these patients alternative treatment methods such as hypnosis could be effective. METHODS The paper presents a case of a 58-year-old man with central neuropathic pain after cervical spinal cord injury. The conservative treatm...

Toxic epidermal necrolysis (TEN) is a serious, life-threatening skin reaction characterized by severe exfoliation and destruction of the epidermis of the skin. In most TEN cases, drugs are believed to be the causative agent; antipsychotics, antiepileptics, and other medications such as sulfonamides are among the most common causes of drug-induced TEN. Phenytoin, a commonly prescribed medication...