Deoxyribonucleic acid (DNA) is an important molecular target for anti-cancer agents due to its involvement in gene expression and protein synthesis which are fundamental steps in cell division and growth. A number of antineoplastic agents interfere with DNA and hence disturb the cell cycle. Compounds including planar aromatic rings are privileged scaffolds in binding to the DNA. This characteri...

To determine the factors that predispose the patient with lung cancer to develop terminal pulmonary infections, we reviewed the case records and autopsy data of 304 patients who died of lung cancer in the Kyushu University Hospital between 1976 and 1990. The incidence of mycobacterial infection was significantly higher among those treated with antineoplastic therapy and corticosteroids (group 3...

Hyponatremia is the most common electrolyte disorder in patients with cancer and associated significant morbidity mortality. Innovation therapies has led to substantial improvement outcomes, but also new therapy-related toxicities, including disturbance. Improvement clinicians understanding of hyponatremia may mitigate adverse outcomes improve quality life patients. In this case-illustrated rev...

The study was undertaken to determine the length of time between when a prescription for an oral antineoplastic agent is written by the provider and when the medication is received by the patient and to identify risk factors that significantly increase time to medication receipt. First-time fill prescriptions for oral antineoplastic agents were identified. The date the prescription was written ...

People over the age of 65 are a fast-growing segment of the US population, and with the incidence of cancer increasing with age, the challenges of treating older cancer patients are also on the rise. Drs. Lichtman and Skirvin present a comprehensive review of the antineoplastic agents used in elderly cancer patients. They highlight the important factors of chemotherapy pharmacology in elderly c...

2008;133;528-538 Chest Bobbak Vahid and Paul E. Marik Antineoplastic Agents for Solid Tumors Pulmonary Complications of Novel http://chestjournal.org/cgi/content/abstract/133/2/528 and services can be found online on the World Wide Web at: The online version of this article, along with updated information ). ISSN: 0012-3692. http://www.chestjournal.org/misc/reprints.shtml ( of the copyright hol...

Persons over the age of 65 years are the fastest growing segment of the United States population. In the next 30 years it will comprise over 20% of the population. Fifty percent of all cancers occur in this age group and therefore there will be an expected rise in the total cancer burden. Data is becoming available which will better guide the use of chemotherapy in the older patient population....

INTRODUCTION Studies on bioavailability are part of the clinical development of drugs for oral use in order to identify potential drug-food interactions. For oral antitumor drugs, their clinical importance is currently recognized although regrettably the information available presents variability concerning the scientific evidence. OBJECTIVES To review the available scientific evidence about ...

The purpose of these guidelines is to assist practitioners in improving their antineoplastic medication-use system and error-prevention programs. They supplement ASHP’s Guidelines on Preventing Medication Errors in Hospitals and address error prevention within diverse health care settings.’ Further, these guidelines provide updated general guidance to include a standard definition of a “medicat...

Purpose The purpose of these guidelines is to assist practitioners in improving their antineoplastic medication-use system and error-prevention programs. They supplement ASHP’s Guidelines on Preventing Medication Errors in Hospitals and address error prevention within diverse health care settings. Further, these guidelines provide updated general guidance to include a standard definition of a “...