Metformin is widely prescribed for the treatment of type II diabetes. Recently, it has been proposed that this compound or related biguanides may have antineoplastic activity. Biguanides may exploit specific metabolic vulnerabilities of transformed cells by acting on them directly, or may act by indirect mechanisms that involve alterations of the host environment. Preclinical data suggest that ...

The object of the present work was formulation and in vitro evaluation of 5-Fluorouracil nanoparticles incorporated in sucralfate suspension as drug delivery system. Sucralfate acts as the cytoproytective agent and carry the antineoplastic drug loaded nanoparticles to the carcinoma site in the g .i.t which will protect and alleviate the carcinoma. 5-Fluorouracil nanoparticles were prepared by n...

Antibody drug conjugates (ADC) are an emerging class of pharmaceuticals consisting cytotoxic agents covalently attached to antibody designed target a specific cancer cell surface molecule followed by internalization and intracellular release payload exhibit its anticancer activity. Targeted delivery variety cells has been demonstrated have significant enhancement in clinical efficacy dramatic r...

Review of the various drugs in current clinical use showed that over 50 of them may cause a purely sensory or mixed sensorimotor neuropathy. These include antimicrobials, such as isoniazid, ethambutol, ethionamide, nitrofurantoin, and metronidazole; antineoplastic agents, particularly vinca alkaloids; cardiovascular drugs, such as perhexiline and hydrallazine; hypnotics and psychotropics, notab...

BACKGROUND Cisplatin is a well-known nephrotoxic antineoplastic drug. Chronic hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria is one of the rare complications associated with its use. CASE PRESENTATION A 42-year-old woman presented with a 20 year-history of hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria after cisplatin-based chemotherapy for ovaria...

125 Determination of Urinary Cyclophosphamide in Oncology Nurses Handling Antineoplastic Drugs by Gas Chromatography-Mass Spectrometry Summary : The aim of the study was to detect exposure to antineoplastic drugs, using cyclophosphamide (CP) as the model compound, in nurses who worked in oncology departments of hospitals. Chemotherapy with antineoplastic agents is often used in the treatment of...

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PROLOGUE This paper discusses the scientific rationale, synthesis, therapeutic utility and clinical limitations of cancer chemotherapy with antineoplastic drugs or toxins covalently linked to monoclonal antibodies directed against tumor cell antigens. Chemical issues that must be considered when designing an effective antineoplastic immunoconjugate or immunotoxin (including purity, functional g...

BACKGROUND Cancer patients receive numerous medications, including antineoplastic agents, drugs for supportive care, and medications for comorbid illnesses. Therefore, they are at risk for drug interactions and duplicate prescribing. METHODS A questionnaire eliciting information on demographics and medications taken in the previous 4 weeks was given to adult outpatients receiving systemic ant...

Cationic polymeric nanoparticles have great potential for developing drug delivery systemswith limited side effects for tumor medication. The goal of this research is investigation ofcationic dextran-spermine polymer (DS) efficacy for improvement of hydrophilic drug deliveryto negatively charged cancerous cells. Capecitabine (as a hydrophilic antineoplastic drug) wasloaded into the magnetic dex...