Chagas disease is a chronic infection caused by Trypanosoma cruzi, an intracellular protozoan parasite. Chronic chagasic patients (CCPs) have dysfunctional CD8+ T cells that are characterized by impaired cytokine production, high coexpression of inhibitory receptors, and advanced cellular differentiation. Most patients diagnosed in the chronic phase of Chagas disease already exhibit heart invol...

Antibiotic G-418 was shown to be superior to paromomycin and metronidazole in cecal amoebiasis. Of particular interest was the high degree of activity seen with a relatively short treatment at low levels. Although the antibiotic was trichomonacidal in vitro at low levels, in vivo results indicated that at levels tested the antibiotic did not always affect cures. The antibiotic appears to have p...

Avian brood parasites reduce the reproductive success of the host, which favours the evolution of antiparasitic defences, such as aggression towards parasites or rejection of their eggs. The red-crested cardinal, Paroaria coronata, is a potential good-quality host of the shiny cowbird, Molothrus bonariensis. However, the frequency of cowbird parasitism in cardinal nests is very low and there ar...

Taenia solium neurocysticercosis (NCC) is a major cause of neurological morbidity in the world. Variability in the neuropathology and clinical presentation of NCC often make it difficult to diagnose and manage. Diagnosis of NCC can be challenging especially in endemic and resource-limited countries where laboratory and imaging techniques are often lacking. NCC management can also be challenging...

Novel derivatives of puberulic acid were synthesized and their antimalarial properties evaluated in vitro against the Plasmodium falciparum K1 parasite strain, cytotoxicity a human diploid embryonic cell line MRC-5, vivo efficacy using berghei-infected mouse model. From previous information that three hydroxy groups on tropone framework essential for activity, we converted carboxylic moiety int...

Abstract Sphingofungins are fungal natural products known to inhibit the biosynthesis of sphingolipids which play pivotal roles in various cell functions. Here, we report a short and flexible synthetic approach towards sphingofungin family. Key step synthesis was decarboxylative cross‐coupling reaction chiral sulfinyl imines with functionalized tartaric acid derivative, yielded core motif sphin...