نتایج جستجو برای: antiproliferative activity

تعداد نتایج: 1139196  

Journal: :Molecules 2016
Hai-Chao Wang Xiao-Qiang Yan Tian-Long Yan Hong-Xia Li Zhong-Chang Wang Hai-Liang Zhu

A series of novel benzohydrazide derivatives containing dihydropyrazoles have been synthesized as potential epidermal growth factor receptor (EGFR) kinase inhibitors and their biological activities as potential antiproliferative agents have been evaluated. Among these compounds, compound H20 exhibited the most potent antiproliferative activity against four cancer cell line variants (A549, MCF-7...

Journal: :Journal of The Serbian Chemical Society 2023

(5R)-Cleistenolide and a few related analogues have been synthesized starting from d-glucose. The key steps of the synthesis included Z-selective Wittig olefination an intramolecular Mitsunobu reaction with inversion configuration at C-5 position. In vitro antiproliferative activity compounds was tested on panel eight human tumour cells against single normal cell line (MRC-5). majority showed s...

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