A quantitative structure activity relationship study was performed on different groups of anti-tuberculosis drug compound for establishing quantitative relationship between biological activity and their physicochemical /structural properties. In recent years, a large number of herbal drugs are promoted in treatment of tuberculosis especially due to the emergence of MDR (multi drug resistance) a...

In the field of medicinal chemistry, Quinazolinone is a heterocyclic compound having unique place which has medicinal uses as Anticancer, antihypertensive, antihyperlipidemic, antitubercular, CNS depressant, antioxidant, analgesic, antibacterial, anti-inflammatory and antimalarial activity. Quinazolinone based drugs have broadened scope in the field of medicine and Research. Some quinazolinone ...

Two new compounds with five known compounds have been isolated from EtOH extract of the seeds of Nigella glandulifera. On the basis of their spectroscopic and chemical evidence, the new compounds were elucidated as methoxynigeglanine (1) and 6-methoxythymol-3-O-β-D-glucopyranoside (4). Compounds 1-4 showed moderate antitubercular activity against Mycobacterium tuberculosis strain H37Rv with min...

A number of mono and bicyclic nitroimidazoles were screened for in vitro antileishmanial activity. Among these, compounds belonging to the class of nitroimidazo[2,1-b]oxazoles showed moderate to good activity. This class of compounds had been reported previously to have pronounced antitubercular activity, particularly CGI17341 (5a). In the present study (5a) and (5d) and (7) were found to be mo...

BACKGROUND Indolinone and spiro-indoline derivatives have been employed in the preparation of different important therapeutic compounds required for treatment of anticonvulsants, antibacterial, Antitubercular, and anticancer activities. Schiff bases have been found to possess various pharmacological activities such as antitubercular, plant growth inhibiting, insecticsidal, central nerve system ...

Pseudomembranous colitis (PMC) may develop with long-term antibiotic administration, but is rarely reported to be caused by antitubercular agents. We present a case of PMC that occurred 120 days after starting rifampicin. A 74-year-old man was diagnosed with pulmonary tuberculosis and started on a standard HERZ regimen (isoniazid, ethambutol, rifampicin, pyrazinamide). After 4 months of HERZ, h...

The most of drugs containing Benzimidazole ring is a prominent structural motif found in numerous therapeutically active compounds. and its synthetic analogues have been to exhibit industrial, agricultural biological application such as antitubercular, anti-inflammatory, analgesic, anticancer, anticoagulant, well good antifungal anti microbial activity. Recent advances technology considers micr...

In the present investigation, a series of 3-(4-methoxyphenyl)-1-isonicotinoyl-5-(substituted phenyl)-formazans (5a-r) were synthesized by condensation of schiff base (3) and diazonium salt of various substituted aromatic amines, (3a-r). The intermediate schiff base (3) was itself synthesized by condensation of isonicotinic acid hydrazide with 4methoxybenzaldehyde (2). The structures of the comp...

Article is based on the different pharmacological activity of the triazole ring, from a last decade a lot of work is going on, on the triazole ring , scientists develop a lot of new compounds related to this moiety and screened them for there different pharmacological activities to get a molecule which have good pharmacological activity and lesser side effect. This review article reflects vario...