Background: Ofloxacin is a fluoroquinolone antibiotic very useful in the treatment of several bacterial infections. The Thiazolidinone ring system represents privileged structure drug discovery. multi-drug-resistant tuberculosis bacteria infects many people worldwide and disease kills 1.8 million annually, so combination ofloxacin-thiazolidinone ...

Objective: Tuberculosis, known in short as TB, is considered to be a global crisis caused by Myco bacterium tuberculosis, and which continues serious challenge public health world wide especially the developing countries. A problem related tuberculosis development of drug resistant strains.
 Methods: Present study describes synthesis eight novel derivatives 1,3,4-thiadiazole vitro evaluati...

A series of triclosan mimic diphenyl ether derivatives have been synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv. The binding mode of the compounds at the active site of enoyl-acyl carrier protein reductase of M. tuberculosis has been explored. Among them, compound 10b was found to possess antitubercular activity (minimum inhibitory ...

Pursuing our search program for new antitubercular drugs we decided to explore the potentiality of pyrrole moiety by molecular modeling and synthesizing novel pyrrole Schiff bases analogues of phthivazid. Enoyl-acyl carrier protein reductase catalyzes the last rate-limiting step in the elongation cycle of the fatty-acid biosynthesis pathway and has been validated as a potential antitubercular d...