نتایج جستجو برای: antituberculosis activity
تعداد نتایج: 1135927 فیلتر نتایج به سال:
Apart from infectious or viral hepatitis, other most common non-infectious causes of hepatitis are alcohol, cholestatic, drugs and toxic materials. The most common mode that leads to liver injuries is antituberculosis drug-induced hepatitis. The severity of drug-induced liver injury varies from minor nonspecific changes in hepatic structure to fulminant hepatic failure, cirrhosis and liver canc...
Invulnerability of Mycobacterium tuberculosis to various drugs and its persistency has stood as a hurdle in the race against eradication of the pathogenecity of the bacteria. Identification of novel antituberculosis compounds is highly demanding as the available drugs are resistant. The ability of the bacteria to surpass the body's defenses and adapt itself to survive for disease reactivation i...
Improved knowledge regarding the tissue penetration of antituberculosis drugs may help optimize drug management. Patients with drug-resistant pulmonary tuberculosis undergoing adjunctive surgery were enrolled. Serial serum samples were collected, and microdialysis was performed using ex vivo lung tissue to measure pyrazinamide concentrations. Among 10 patients, the median pyrazinamide dose was ...
Given the urgent need for designing a new antituberculosis vaccine conferring total protection on patients of all ages, following the line of research adopted by our institute, this work has identified Mycobacterium tuberculosis (Mtb) Rv3166c protein high-activity binding peptides (HABPs) which are able to inhibit bacterial invasion of U937 (monocyte-derived macrophages) and A549 (type II alveo...
r The 1938 report of the work m (Anti-Tuberculosis) Fund on by that bo Jsig *as the last report to be ^ ror's Anti-Tube ciation Fund was along with King-E P ^erculosns A Fund incorporated into the^u?|39. The settmg^.^ ?f India on the 23rd Februa y^e tuberculosis n of the central and province pl, ncy's ??=+ tubertions as a result of Her Exf hency^ against tu^ a renewed life to the whole ^ vcry i...
Introduction: Aloe vera has anti-bacterial ability against Gram-positive and Gram-negative bacteria; however, study, especially in multidrug resistant strain of Mycobacterium tuberculosis, not been evaluated yet. This study aims to determine the potential as an antituberculosis drug-resistant strains tuberculosis. Method: Stages research include production ethanol extract vera, then testing phy...
BACKGROUND Tuberculous meningitis is often lethal. Early antituberculosis treatment and adjunctive treatment with glucocorticoids improve survival, but nearly one third of patients with the condition still die. We hypothesized that intensified antituberculosis treatment would enhance the killing of intracerebral Mycobacterium tuberculosis organisms and decrease the rate of death among patients....
Altered pharmacokinetics of antituberculosis drugs may contribute to an increased risk of tuberculosis treatment failure for diabetic patients. We previously found that rifampin exposure was 2-fold lower in diabetic than in nondiabetic tuberculosis patients during the continuation phase of treatment. We now examined the influence of diabetes on the pharmacokinetics of antituberculosis drugs in ...
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