Follicle development is accompanied by proliferation of granulosa cells and increasing oocyte size. To obtain high-quality oocytes in vitro, it is important to understand the processes that occur in oocytes and granulosa cells during follicle development and the differences between in vivo and in vitro follicle development. In the present study, oocytes and granulosa cells were collected from e...

In the present study, we evaluated the contributions of antral follicle development and antral granulosa cell-released factor(s) to the acquisition of a mature mouse oocyte plasma membrane organization and cortical granule distribution. This has been performed by comparing in-vitro matured oocytes derived from early antral follicles (here referred to as denuded oocytes) or from pre-ovulatory fo...

Title of Thesis: DETERMINATION OF THE DYNAMICS OF FELINE FOLLICLE METABOLISM Jennifer L. Colvin, Master of Science, 2013 Thesis Directed By: Associate Professor Brian J. Bequette, Department of Animal and Avian Sciences The metabolism of feline follicles has been largely overlooked in reproductive science. The primary objective of this study was to determine differences in metabolite profiles a...

BACKGROUND The current study was designed to compare antral follicle count (AFC) and basal ovarian volume (BOV), the exogenous FSH ovarian reserve test (EFORT) and the clomiphene citrate challenge test (CCCT), with respect to their ability to predict poor and hyper responders. METHODS One hundred and ten regularly menstruating patients, aged 18-39 years, participated in this prospective study...

apparent rise in the incidence of infertility in females and the trend shifting towards delayed child bearing brought up the concept of ovarian ageing. women in their early thirties show poor ovarian reserve which is an entity named as early ovarian ageing. early ovarian ageing is mostly genetically determined, but acquired modifiable factors like smoking, or ovarian surgery have some roles. in...

Background: Recent improvement in treatments of cancer has significantly increased survival rates of cancer patients. Unfortunately these treatments such as chemotherapy and radiotherapy can sever damage to the ovaries. Ovarian cryopreservation prior to chemo/ radiotherapy and auto-transplantation post-treatment can restore fertility to cancer patients. Hypoxia in the transplant from delayed re...

CONTEXT Ovarian dysfunction is classically categorized on the basis of cycle history, FSH, and estradiol levels. Novel ovarian markers may provide a more direct insight into follicular quantity in hypergonadotropic women. OBJECTIVE The objective of the study was to investigate the distribution of novel ovarian markers in young hypergonadotropic women as compared with normogonadotropic regular...

.......................................................................................... xiv Research Publications ................................................................... xviii Conference abstracts ..................................................................... xix Chapter 1: Introduction ..................................................................... 2 1.1 Folliculoge...

ObjectiveTo characterize circulating insulin-like factor 3 (INSL3) in different stages of ovarian insufficiency and its role the evaluation premature (POI).DesignRetrospective cohort study.SettingUniversity-based center for reproductive medicine.Patient(s)A total 145 women, including 48 patients with POI (25 IU/L < follicle-stimulating hormone [FSH] ?40 IU/L), 49 biochemical (bPOI) (10 FSH ?25 ...

STUDY OBJECTIVE Preliminary data on the effects of prophylactic bilateral salpingectomy (PBS) show that postoperative ovarian function is preserved up to 3 months after surgery. The confirmation of PBS safety on ovarian function even many years after surgery is essential to reassure the medical community that this new strategy, recently proposed for the prevention of ovarian cancer, is at least...