Transgenic restoration of normally absent H2-E MHC class II molecules on APC dominantly inhibits T cell-mediated autoimmune diabetes (IDDM) in nonobese diabetic (NOD) mice. We analyzed the minimal requirements for transgenic H2-E expression on APC subtypes (B lymphocytes vs macrophages/dendritic cells (DC)) to inhibit IDDM. This issue was addressed through the use of NOD stocks transgenically e...

Activated protein C-resistance (APC-resistance) (6) is the most common inherited genetic disorder responsible for venous thrombosis (13). Over 90% of APC-resistances are caused by a single-base mutation, G/A 1691 in the factor V gene, also known as factor V Leiden. This mutation, changing Arg 506 to Gln, impedes the cleavage of factor Va by APC (3,7,14). APC-resistance is routinely determined b...

conclusions acute poisoning in children is a serious preventable cause of hospital admissions. it is one of the differential diagnoses in patients with sudden onset of neurological, alimentary, respiratory symptoms and signs, who are visited at the emergency department. parental awareness and education about keeping potential poisoning agents safely is essential to reduce apc in children. backg...

Recently, self-supervised learning (SSL) from unlabelled speech data has gained increased attention in the automatic recognition (ASR) community. Typical SSL methods include autoregressive predictive coding (APC), Wav2vec2.0, and hidden unit BERT (HuBERT). However, models are biased to pretraining data. When finetuned with another domain, domain shifting occurs might cause limited knowledge tra...

The objective of this study was to establish whether or not patients with unexplained recurrent abortion have an increased incidence of haemostatic or metabolic abnormalities. Fifty-two patients with a history of unexplained habitual abortion (two or more spontaneous abortions before 16 weeks' gestation) were tested for protein S, protein C and antithrombin (AT) III deficiency, activated protei...

In a recently published paper in Blood,1 Kemmeren et al elegantly studied the effect of secondand third-generation oral contraceptives (OCs) on hemostatic variables that probe the activity of the protein C system. The authors showed that, because the progestagen poorly counteracted the effect of the estrogen component, desogestrel-containing OCs significantly increased activated protein C (APC)...

BACKGROUND AND OBJECTIVE Activated protein C (APC)-resistance, the most common risk factor for venous thrombosis described so far, is due to a single point mutation in the factor V gene. As a result, inactivation of factor-activated factor V by APC is impaired, which leads to a hypercoagulable state and a lifelong increased risk of thrombosis. The importance of protein S as an anticoagulant pro...

How did it get its name? APC is short for adenomatous polyposis coli. The APC gene is mutated in familial adenomatous polyposis, a hereditary form of colon cancer. Carriers of APC mutations develop thousands of colon tumours, some of which inevitably progress to malignancy. Inactivating mutations in APC are also found in the large majority of sporadic colon cancers. APC is therefore an importan...