Background: The anti-cancer effects of honey bee venom (BV) and chrysin might open a new window for treatment of chemo-resistant cancers. This study was designed to evaluate cytotoxic and pro-apoptotic effects of BV and chrysin on A2780cp cistplatin- resistant human ovarian cancer cells. Methods: As per the study objectives, A2780cp cells were categorized to 4 groups: 3 experiment groups (treat...

Glioma is the most common primary tumor of human central nervous system. It characterized by fast growth, strong invasion and impossible to complete surgical resection. Despite advances in diagnosis treatment, including surgery, radiotherapy chemotherapy, median survival for WHO Grade II gliomas 5 years, III 2-3 IV 14.6 months. The study glioma cell formation mechanism great significance treatm...

Heamatang (HMT) is a classic medicinal formula used in traditional Chinese and Korean medicine; it contains seven distinct components, mainly of herbal origin. HMT as an antiaging remedy, treating urinary disorders increasing energy vitality. However, the therapeutic applications this have not been evaluated with evidence-based science. Therefore, we assessed through various vitro methods, incl...

We evaluated the effects of zoledronic acid (ZOL) on human gingival fibroblasts (HGFs) and umbilical vein endothelial cells (HUVECs) associated with wound healing in oral soft tissues. HGFs HUVECs were divided into two groups: a culture media control group exposed to ZOL (50 μM). Cell proliferation was measured after 2, 4, 6, 8 days. The migration ability for each experiment using assay. apopto...

BACKGROUND Oxidative stress, inducing cardiomyocyte apoptosis or myocardial ischemia, is the major denominator of many cardiac diseases. In this study, we intended to explore the regulatory function of microRNA-137 (miR-137) in oxidative stress-induced cardiomyocyte apoptosis. MATERIAL AND METHODS Cardiomyocytes were extracted from newborn C57BL/6 mice and cultured in vitro. Apoptosis was ind...

Background: Geraniol has been shown to possess therapeutic or preventive effects against various types of human cancers but not affect normal physiology through regulating cell cycle and apoptosis. However, the biological geraniol on oral squamous carcinoma (OSCC) cells are unknown.
 Methods: OSCC proliferation was measured by cell-counting kit-8 colony formation assays. Cell migration ass...

Objective(s) Cigarette and nicotine enhances embryogenesis, fertility, pregnancy loss and ultrastructure alterations of oocyte. This study was performed to determine the effect of daily supplementation of vitamin E on oocytes apoptosis in nicotine-treated mice. Materials and Methods In this experimental study, 24 NMARI adult female mice were randomly allocated into four experimental groups. ...

background and aims. there is no report on the apoptotic impact of allium sativum l. (garlic) on the oral squamous cell carcinoma (kb); hence, this study was designed to survey the apoptotic effects of garlic fresh juice (gfj) on the kb cells. materials and methods. mtt assay (microculture tetrazolium assay) was carried out to evaluate the cytotoxicity of gfj on kb cells. furthermore, tunel (te...