نتایج جستجو برای: apoptosis inflammasomes resveratrol

تعداد نتایج: 164971  

2011
Souvik Roy Santanu Sannigrahi Subhabrota Majumdar Balaram Ghosh Biswajit Sarkar

Recent studies indicate the chemopreventive role of resveratrol in many animal models like ischemia, rheumatoid arthritis, human cancer, and diabetes. The present study was designed to investigate the chemopreventive potential of resveratrol in rat hepatic injury model by carbon tetrachloride. Male Wistar rats were treated with carbon tetrachloride (0.4 g/kg body weight) intraperitoneally daily...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Kun Yin Liang Zhao Dan Feng Wenya Ma Yu Liu Yang Wang Jing Liang Fan Yang Chongwei Bi Hongyang Chen Xingda Li Yanjie Lu Benzhi Cai

BACKGROUND/AIMS Low ambient temperature is an important risk factor for cardiovascular diseases, and has been shown to lead to cardiac hypertrophy. In this study, we aim to investigate if Resveratrol may inhibit cold exposure-induced cardiac hypertrophy in mice, and if so to clarify its molecular mechanism. METHODS Adult male mice were randomly assigned to Control group (kept at room temperat...

2014
Peng Zhang Hong Li Bin Yang Fan Yang Lin-Lin Zhang Qing-You Kong Xiao-Yan Chen Mo-Li Wu Jia Liu

Cervical cancers/CCs are one of the commonest malignancies and the second leading cause of cancer-related death in women. Resveratrol inhibits CC cell growth but its molecular target(s) remains unclear. Since the signaling pathways mediated by STAT3, Notch1 and Wnt2 play beneficial roles in CC formation and progression, the effects of resveratrol on them in cervical adenocarcinoma (HeLa) and sq...

2013
Qing Yang Bo Wang Wen Zang Xuping Wang Zhifang Liu Wenjuan Li Jihui Jia

Resveratrol, a naturally occurring polyphenolic compound, has been reported to exert anticancer activity by affecting diverse molecular targets. In this study, we examined the effects and the underlying mechanisms of resveratrol on gastric cancer. We found that resveratrol inhibited the proliferation of gastric cancer cells in a dose-dependent manner. At the concentration of 25 and 50 µM, resve...

2014
Anantha Harijith David L. Ebenezer Viswanathan Natarajan

Inflammasomes form a crucial part of the innate immune system. These are multi-protein oligomer platforms that are composed of intracellular sensors which are coupled with caspase and interleukin activating systems. Nod-like receptor protein (NLRP) 3, and 6 and NLRC4 and AIM2 are the prominent members of the inflammasome family. Inflammasome activation leads to pyroptosis, a process of programm...

Journal: :Indian Journal of Pharmaceutical Sciences 2021

To analyze the effect of resveratrol on myocardial remodeling and cardiac function after infarction by inhibiting cell apoptosis through regulating silent information regulator 1/protein kinase R-like endoplasmic reticulum pathway. 32 healthy male sprague dawley rats were divided into control group (without any treatment), model (ligation left anterior descending branch to establish a model), s...

Journal: :Sains Malaysiana 2021

Endoplasmic reticulum (ER) stress can induce autophagy via the unfolded protein response (UPR), and regulate activation of inflammasomes. Inositol-requiring enzyme 1α (IRE1α) is a transducer UPR in cells with ER stress. Here, we investigated role IRE1α its impact on rheumatoid arthritis fibroblast-like synovial (RA-FLSs). RA-FLSs were isolated from (RA) patients stimulated thapsigargin (TG) to ...

Journal: :iranian journal of pharmaceutical research 0
meherzia mokni neurophysiology laboratory and functional pathology, department of biological sciences, faculty of sciences of tunis, university campus of al-manar, tunisia, tunis. sonia hamlaoui neurophysiology laboratory and functional pathology, department of biological sciences, faculty of sciences of tunis, university campus of al-manar, tunisia, tunis. ines karkouch bioactive substance laboratory, biotechnology centre, technopolis borj-cedria, bp-901, 2050 hammam-lif, tunis. mohamed amri neurophysiology laboratory and functional pathology, department of biological sciences, faculty of sciences of tunis, university campus of al-manar, tunisia, tunis. lamjed marzouki neurophysiology laboratory and functional pathology, department of biological sciences, faculty of sciences of tunis, university campus of al-manar, tunisia, tunis. ferid limam bioactive substance laboratory, biotechnology centre, technopolis borj-cedria, bp-901, 2050 hammam-lif, tunis.

in this study, we investigated the cardioprotective effects of resveratrol. rats were intraperitoneally administered with resveratrol (25 mg/kg bw) or vehicle (ethanol 10%) for 7 days and their heart subjected to ischemia/reperfusion injury. isolated hearts were langendorff perfused, left ventricular functions as heart rate and developed pressure, as well as, heart antioxidant status were deter...

Journal: :Archives of Medical Science 2021

Introduction Resveratrol, a polyphenol extracted from many plant species, has emerged as promising pro-apoptotic agent in various cancer cells. However, the role of resveratrol cell proliferation and apoptosis fibroblast-like synoviocytes rheumatoid arthritis (RA-FLS) is not fully understood. The study was aimed at elucidating RA-FLS underlying molecular mechanism. Material methods Cultured RA-...

2012
Yuichiro Kita Yutaka Miura Kazumi Yagasaki

Piceatannol is a stilbenoid, a metabolite of resveratrol found in red wine. Piceatannol and sera from rats orally given piceatannol were found to dose-dependently suppress both the proliferation and invasion of AH109A hepatoma cells in culture. Its antiproliferative effect was based on cell cycle arrest at lower concentration (25~50 μM) and on apoptosis induction at higher concentration (100 μM...

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