PURPOSE To evaluate the effect of caffeine on the apoptosis rate of giant cell tumour of bone cells during thermoablation. METHODS Giant cell tumour of bone tissue (2 cm3) was collected from 10 patients. Cells were incubated at 37ºC, 40ºC, 45ºC, 50ºC, 52.5ºC, and 55ºC for 20 minutes (3 tubes for each temperature). Caffeine was added to the tubes in amounts of 0 μg/ml (control), 50 μg/ml, and ...

Apoptotic cell clearance by macrophages and neighbouring tissue cells induces hepatocyte growth factor (HGF) secretion. HGF plays a key role in alveolar epithelial regeneration and reconstruction after lung injury. Direct in vivo exposure to apoptotic cells enhances HGF production, resulting in attenuation of pulmonary injury. We investigated the direct effect of in vivo exposure to apoptotic c...

objective: the goals of the study are evaluation the effect(s) of food deprivation as a social stress on testis structure. we also investigated the effects of melatonin treatment as an antioxidant component and inequality on the effect(s) of food deprivation. methods: we investigated the improving effects of melatonin and social stress (food deprivation) on 42 male rats in 7 groups including co...

background: it is well known that the hippocampus, the ca1 pyramidal cells in particular, is selectively vulnerable during global cerebral ischemia. recently, it is observed that pentoxifylline has a neuroprotective effect. this study explored the pharmacological relationship between ischemia-induced cell death of the hippocampus and the efficacy of a vasodilator agent (pentoxifylline) in the p...

background: quercetin is a strong antioxidant and long-term treatment of stz-diabetic animals and it has been shown to reduce oxidative stress.   objective: antioxidants have essential effect on spermatogenesis and sperm parameters. enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus.   methods: ...

the apoptotic protease-activating factor 1 (apaf-1) receives the death signal in the intrinsic ormitochondrial pathway of apoptosis. upon the releasing of cytochrome c from theintermembrane space of mitochondria and binding to apaf-1 molecules, a heptamericapoptosome complex is formed and triggers the downstream cascade of caspases. here, for thefirst time we present spontaneous mutations and r...

Background: Diazinon (DZN) is an organophosphate insecticide widely utilized in agriculture all over the world and causes many negative effects on plants and animal species, especially on human. The aim of present study was to evaluate the effects of DZN on apoptosis of ovarian follicles in adult rats and to assess the protective role of vit E. Methods: Thirty adult female Wistar rats were d...

In this study, we compared the effects of terpinolene against anti-cancer agent cisplatin on proliferation, apoptotic activity and intracellular ROS (reactive oxygen species) production in cancerous (MCF-7) non-cancerous (HEK-293) cell lines. Cisplatin presented a strong growth-inhibitory effect both MCF-7 (IC25: 18.77 µM) HEK-293 15.03 The was found to be weaker than 291.18 µM for 345.35 HEK 2...

The aim of our study was to investigate the effect inflammation in placenta on pro-apoptotic development after severe preeclampsia. Placenta tissue samples 15 HELLP syndrome and healthy 35-38th week-pregnant women were involved study. Tissue taken only from maternal side fixed 10 % formaldehyde, then blocked paraffin wax 4-6 mm-thick sections cut stained with Harris Hematoxylene-Eosin. Antigen ...