Although minoxidil has been used for more than two decades to treat androgenetic alopecia (AGA), an androgen-androgen receptor (AR) pathway-dominant disease, its precise mechanism of action remains elusive. We hypothesized that minoxidil may influence the AR or its downstream signaling. These tests revealed that minoxidil suppressed AR-related functions, decreasing AR transcriptional activity i...

Genetic disruption of the steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF)2/SRC-2 in mouse resulted in distinctive mutant phenotypes. To quantify their roles in the function of androgen receptor (AR) transcriptional activity in vivo, we generated a unique transgenic AR-reporter mouse and analyzed the cell-specific contributions of SRC-1 and TIF2 to the activity...

El presente estudio de investigación demuestra que es viable la recuperación oro y zinc en minerales marmatitico con contenido oro. Se analizó mediante diseños experimentales factoriales, utilizando los reactivos: CuSO4, AR-3418 AR-1242 como variables independientes; el resto las se mantuvieron constantes.
 Como resultado obtuvo un modelo para zinc, realizando análisis del diseño factorial...

Despite the progress in development of better AR-targeted therapies for prostate cancer (PCa), there is no curative therapy for castration-resistant prostate cancer (CRPC). Therapeutic resistance in PCa can be characterized in two broad categories of AR therapy resistance: the first and most prevalent one involves restoration of AR activity despite AR targeted therapy, and the second one involv...

Advanced prostate cancer is responsive to hormone therapy that interferes with androgen receptor (AR) signalling. However, the effect is short-lived, as nearly all tumours progress to a hormone-refractory (HR) state, a lethal stage of the disease. Intuitively, the AR should not be involved because hormone therapy that blocks or reduces AR activity is not effective in treating HR tumours. Howeve...

Autophagy is an evolutionarily conserved process responsible for the degradation and recycling of cytoplasmic components through autolysosomes. Targeting AR axis is a standard strategy for prostate cancer treatment; however, the role of AR in autophagic processes is still not fully understood. In the present study, we found that AR played a negative role in AR degrader celastrol-induced autopha...

Introduction: Miller Range 99301 is a type 6, unbrecciated LL chondrite [1]. MIL 99301 is of interest because some compositional and petrographic features suggest it experienced rather high shock grades, whereas other features suggest it is relatively unshocked. Inconsistent shock indicators could be explained if MIL 99301 was shocked but then partly annealed by heat produced by impacts on the ...

A comparison of the adsorption efficiencies for Ar atoms on large (N2)m (m = 1320−10600) clusters and N2 molecules on large (Ar)n (n = 7900−17000) clusters has been investigated by the pick-up technique. Using mass spectroscopy, it has been shown that mixed (Ar)n(N2)m clusters can be created either by depositing Ar atoms from buffer gas on the surface of (N2)m clusters or by depositing N2 molec...