BACKGROUND AND PURPOSE L1 cell adhesion molecule (L1CAM) has been observed to be aberrantly expressed and implicated in progression of several types of human cancers. However, its roles in breast cancer have not been fully elucidated. In this study, we aimed to investigate the clinical significance of L1CAM in human breast cancer and to validate whether it participates in cancer cell migration ...

Epigenetic modifications are involved in breast carcinogenesis. Identifying genes that are epigenetically silenced via methylation could select target patients for diagnostic as well as therapeutic potential. We assessed promoter methylation of breast cancer susceptibility gene 1 (BRCA1) and 17 Beta Hydroxysteroid Dehydrogenase Type 1 (17βHSD-1) in normal and cancer breast tissues of forty spor...

background : breast cancer is one of the most frequent malignancies among iranian women. triple-negative breast cancer (tnbc) is referred to a type of breast cancer which three biomarkers of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (her2), are negative. materials and methods: in this case control study, immunohistopathologic data of patients with tn...

background: inflammatory breast cancer (ibc), a subgroup of locally advanced breast cancer (labc), is diagnosed based on clinical findings, and seems to be different from other types of labc. the purpose of this study was to compare clinicopathological characteristics and outcomes between inflammatory and non-inflammatory labc patients at breast cancer research center (bcrc), tehran, iran. meth...

Introduction FENDRR is a long non-coding RNA (lncRNA) that mediates the modification of the epigenetic landscape of target promoters by binding to polycomb repressive complex 2. However, the role of FENDRR in breast cancer remains unknown. Materials and methods We detected the expression of FENDRR in 52 breast cancer patients' tissues and five breast cancer cell lines. The association between...

Programmed cell death 4 gene (PDCD4), an in vivo repressor of transformation, was originally isolated from a human glioma library by screening it with an antibody against a nuclear antigen in proliferating cells. PDCD4 functions as a transformation repressor by inhibiting the activity of the RNA helicase, eIF4A. We previously showed that retinoids, anti-estrogens and HER2/neu antagonist induce ...

Histopathology forms the gold standard for the diagnosis of breast cancer. Multiphoton microscopy (MPM) has been proposed to be a potentially powerful adjunct to current histopathological techniques. A label-free imaging based on two- photon excited fluorescence and second-harmonic generation is developed for differentiating normal breast tissues, benign, as well as breast cancer tissues. Human...

Aims: The present study is to investigate the expression of thyroid hormone responsive spot 14 homolog (Thrsp) and thyroid hormone receptor β1 (TRβ1) proteins in human breast cancer tissues and adjacent tissues, as well as its relationship with clinical pathological data of breast cancer patients. Methods: A total of 112 Uygur and Han patients with breast invasive ductal carcinoma and lobular c...

background: determining the optimal and effective scheme for administrating the chemotherapy agents in breast cancer is the main goal of this scientific research. the most important issue here is the amount of drug or radiation administrated in chemotherapy and radiotherapy for increasing patient's survival. this is because in these cases, the therapy not only kills the tumor cells, but also ki...

Background: Ras-associated domain family 1 (RASSF1A) and hypermethylated in cancer (HIC1) genes are methylated more frequently in breast cancer. Genetic factors that alter the DNA methylation levels in normal and tumor tissues could therefore influence the susceptibility to this tumor phenotype. Objective: We determined the frequency of aberrant methylation of HIC1 and RASSF1A gene promoters an...