The area under the ROC curve (AUC) is a well-known measure of ranking performance, and is also often used as a measure of classification performance, aggregating over decision thresholds as well as class and cost skews. However, David Hand has recently argued that AUC is fundamentally incoherent as a measure of aggregated classifier performance and proposed an alternative measure [5]. Specifica...

The Visual Concept Detection Task (VCDT) of ImageCLEF 2008 is described. A database of 2,827 images were manually annotated with 17 concepts. Of these, 1,827 were used for training and 1,000 for testing the automated assignment of categories. In total 11 groups participated and submitted 53 runs. The runs were evaluated using ROC curves, from which the Area Under the Curve (AUC) and Equal Error...

Method The study was designed as prospective randomized double blind non-inferiority trial. Primary end-point was area under the curve (AUC) of creatine kinase MB (CKMB) within the first 24 hours after surgery. Secondary endpoints included, peak CKMB and troponin-T and AUC of troponin-T release, cardiac index, cumulative catecholamine dose, ICU-stay and mortality. All values are given as mean ±...

background: metabolic syndrome (metsy), an important predisposing factor for the most of noncommunicable diseases, has become a global pandemic. given different definitions used for the metsy, recently using a score termed “continuous metsy risk score (cmetsys)” is recommended. the aim of this study was to provide a cmetsys in a population-based sample of iranian adults and to assess its determ...

The area under the ROC curve (AUC), a wellknown measure of ranking performance, is also often used as a measure of classification performance, aggregating over decision thresholds as well as class and cost skews. However, David Hand has recently argued that AUC is fundamentally incoherent as a measure of aggregated classifier performance and proposed an alternative measure (Hand, 2009). Specifi...

The Visual Concept Detection Task (VCDT) of ImageCLEF 2008 is described. A database of 2,827 images were manually annotated with 17 concepts. Of these, 1,827 were used for training and 1,000 for testing the automated assignment of categories. In total 11 groups participated and submitted 53 runs. The runs were evaluated using ROC curves, from which the Area Under the Curve (AUC) and Equal Error...

Variability in valacyclovir bioavailability and the potential for cephalexin-valacyclovir interaction were evaluated. The intraindividual acyclovir area under the concentration-time curve (AUC) varied minimally, whereas interindividual differences were substantial. Coadministration of the human peptide transporter 1 (hPEPT1) substrates valacyclovir and cephalexin minimally reduced the acyclovir...

Methods We launched a non-interventional study with analysis of clinical, biological and pharmacokinetic information. Full-PK profiles of MPA were modelled using an iterative two-stage approach (1). The clinical status was defined by the SLEDAI, the SLE being considered active for a score ≥6. Relationships between MPA through concentrations (C0), AUC (Area Under Curve) or AUC/ dose values, and ...