Abstract Multidrug-resistant (MDR) bacteria are a significant contributor to the global antibiotic resistance crisis, which is predicted kill more people than cancer by 2050. Livestock production contributing factor as it has been one of fastest-growing industries in previous century but most harmful effects on environment and human health. The pig widely raised consumed food-producing animal g...

OBJECTIVE To identify the major aggrecanase- and matrix metalloproteinase (MMP)-generated aggrecan fragments in human osteoarthritis (OA) synovial fluid and in human OA joint cartilage. METHOD Aggrecan fragments were prepared by CsCl gradient centrifugation. Fragment distributions were compared with aggrecanase-1 (ADAMTS-4) and MMP-3 digested human aggrecan by analysis with neoepitope antibod...

Over the last decade, Alternate Reality Games (ARGs), a form of narrative often involving multiple media and gaming elements to tell a story that might be affected by participants’ actions, have been used in the marketing and promotion of a number of entertainment related products such as films, computer games and music. This paper discusses the design, development and evaluation of an ARG aime...

BACKGROUND Antimicrobial agents have been widely used in animal farms to prevent and treat animal diseases and to promote growth. Antimicrobial agents may change the bacterial community and enhance the resistome in animal feces. We used metagenome-wide analysis to investigate the changes in bacterial community, variations in antibiotic resistance genes (ARGs), and their bacterial hosts in the f...

BACKGROUND The evolution of antibiotic-resistant bacteria (ARB) and antibiotic-resistance genes (ARGs) has been accelerated recently by the indiscriminate application of antibiotics. Antibiotic resistance has challenged the success of medical interventions and therefore is considered a hazardous threat to human health. OBJECTIVES The present study aimed to describe the use of zinc finger nucl...

A series of Antibody Recruiting Glycodendrimer (ARG) was screened against the melanoma cell line M21. We identified lead ARGs that promote up to 57% selective cytotoxicity in presence human serum as unique source immunity effectors.

Abstract Background Antibiotic-resistant bacteria (ARB) usually enter water sources in different ways, such as via municipal and hospital wastewaters. Because conventional technologies used to treat inefficient removing these contaminants (especially antibiotic-resistant genes; ARGs), easily drinking distribution networks pose serious threats consumers’ health. This study’s main purpose is syst...

Antibiotic resistance has become a global threat in which the anthropogenically influenced aquatic environment represents not only reservoir for spread of antibiotic resistant bacteria (ARB) among humans and animals but also an where genes are introduced into natural microbial ecosystems. Wastewater is one sources resistance. The aim this research was evaluation wastewater impact on water envir...

Antibiotic resistance genes (ARGs) became an emerging contaminant, and were found to accumulate in natural man-made environments. A comprehensive understanding of the diversity abundance ARGs pristine environments is critical for defining baseline levels environmental ARGs. However, there limited information available on ARG profiles environments, especially shallow-sea hydrothermal vents ecosy...