We have cloned a homologue of the homeotic gene Abdominal-B from the locust Schistocerca gregaria and raised antibodies against the homeodomain and C-terminal flanking region of the encoded protein. This antibody stains the posterior abdomen of the developing Schistocerca embryo from 26% of development onwards, a stage when only the anterior of the abdomen is visibly segmented. By the time segm...

Sexual dimorphism requires the integration of positional information in the embryo with the sex determination pathway. Homeotic genes are a major source of positional information responsible for patterning along the anterior-posterior axis in embryonic development, and are likely to play a critical role in sexual dimorphism. Here, we investigate the role of homeotic genes in the sexually dimorp...

Muscular dystrophy (MD) is the most common genetic lethal disorder in children. Mutations in dystrophin trigger the most common form of MD, Duchenne, and its allelic variant Becker MD. Utrophin is the closest homologue and has been shown to compensate for the loss of dystrophin in human disease animal models. However, the structural and functional similarities and differences between utrophin a...

A fragment of type theory with OWL class constructions for types and binary properties is used to formalize SysML Structural Block Diagram models. A structural SysML block diagram model is a model that does not have behavior in the sense that values of properties do not change. A structural model may include properties, variables and operations. Individuals are a special case of operators with ...

The homeotic genes in Drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This posterior dominance rule must be qualified in the case of abdominal-A (abd-A) repression by Abdominal-B (Abd-B). Animals lacking Abd-B show ectopic expression of abd-A in the epidermi...

shawāhid al-nabuwwa of ‘abd al-raḥmān jāmī (d. 898/1492) is among the books written by one of the sunnī scholars who has authored it with a sufi taste. in this book, jāmī has addressed the life of the prophet (s.a.w.), the twelve imams (a.s.), and the companions (ṣaḥāba) with a miracle-oriented approach and has presented precisely the same reports about the imams (a.s.) that are found in shī‘ī ...