Multiple-input multiple-output (MIMO) significantly increases the throughput of a communication system by employing multiple antennas at the transmitter and the receiver. To extract maximum performance from a MIMO system, a computationally intensive search based detector is needed. To meet the challenge of MIMO detection, typical suboptimal MIMO detectors are ASIC or FPGA designs. We aim to sho...

This paper overviews advantages and disadvantages of CMOS and CCD matrixes used in endoscopic capsules, specifies requirements that should be met by the microcontroller of the device for the improvement of its effectiveness and concludes on the need of developing the application-specific integrated circuit (ASIC) for the wireless endoscopic capsule. The ASIC microcontroller designed especially ...

— Architectures for wireless systems have traditionally been designed to meet real-time requirements, t on a limited die area, and operate within a low power budget. These conditions are usually met by implementing compute-intensive operations in an application speci c integrated circuit (ASIC). ASIC design is both expensive and time consuming. ASICs also suffer in that even minor evolutionary ...

The epithelial Na(+) channel (ENaC) and acid-sensitive ion channel (ASIC) branches of the ENaC/degenerin superfamily of cation channels have drawn increasing attention as potential therapeutic targets in a variety of diseases and conditions. Originally thought to be solely expressed in fluid absorptive epithelia and in neurons, it has become apparent that members of this family exhibit nearly u...

Acid-sensing ion channels (ASICs) are key receptors for extracellular protons. These neuronal nonvoltage-gated Na(+) channels are involved in learning, the expression of fear, neurodegeneration after ischemia, and pain sensation. We have applied a systematic approach to identify potential pH sensors in ASIC1a and to elucidate the mechanisms by which pH variations govern ASIC gating. We first ca...

A proposed design for a reconfigurable x-ray Pixel Array Detector (PAD) is described. It operates by integrating a high-end commercial field programmable gate array (FPGA) into a 3-layer device along with a high-resistivity diode detection layer and a custom, application-specific integrated circuit (ASIC) layer. The ASIC layer contains an energy-discriminating photon-counting front end with pho...

With the advantages of small size, reliability, rapid response, compatibility to standard CMOS technology and on-chip signal processing, Ion-Sensitive Field Effect Transistor (ISFET)-based transducers are increasingly being applied in physiological data acquisition and environment monitoring. This paper presents a signal processing Application Specific Integrated Circuit (ASIC) and a discrete t...

Acid-sensing ion channels (ASICs) constitute a family of neuron-specific voltage-insensitive sodium channels gated by extracellular protons. Functions of ASICs in mammals include nociception, mechanosensation, and modulation of synaptic transmission. However, the role protons play in mediating the effects of ASICs remains elusive. We have examined ASICs from the ascidian Ciona intestinalis, a s...

Traditionally, focal plane arrays require extensive external focal plane electronics (FPE) to provide clocks and biases as well as to digitize the analog output signals. The FPE has to be well-designed and is typically large, heavy and powerhungry. Most importantly, the FPE has to be placed some distance away from the FPA, which complicates maintaining low noise performance throughout the compl...

Acid-sensing ion channels (ASICs) are sodium channels gated by extracellular protons. ASIC1a channels possess intersubunit Cl(-)-binding sites in the extracellular domain, which are highly conserved between ASIC subunits. We previously found that anions modulate ASIC1a gating via these sites. Here we investigated the effect of anion substitution on native ASICs in rat sensory neurons and hetero...