The aim of the study. To identify frequency occurrence TLR4 Asp299Gly (rs4986790) gene polymorphism and to establish its contribution development organ dysfunction in patients with severe pneumonia associated A/H1N1 influenza. Materials methods . study included 55 Inclusion criteria: pneumonia; consolidation/ground-glass syndrome according chest X-ray/CT. Exclusion unstable hemodynamics; body m...

Two common single nucleotide polymorphisms (SNPs) of the human TLR4 gene, namely Asp299Gly (D299G) and Thr399Ile (T399I), have been shown to impair the ability of certain individuals to respond properly to TLR4 ligands. 5-Fluorouracil (5-FU) is widely used for the treatment of patients with advanced colon cancers. The present study examined the impact of two common polymorphisms of the TLR4 gen...

two common single nucleotide polymorphisms (snps) of the human tlr4 gene, namely asp299gly (d299g) and thr399ile (t399i), have been shown to impair the ability of certain individuals to respond properly to tlr4 ligands. 5-fluorouracil (5-fu) is widely used for the treatment of patients with advanced colon cancers. the present study examined the impact of two common polymorphisms of the tlr4 gen...