Abstract   Background: The disrupted-in-schizophrenia 1 (DISC1) gene, on the chromosome   position 1q42, was initially identified at the breakpoint of a balanced translocation,   t(1,11)(q42.1q14.3), which segregated with major mental disorders in a large   Scottish family.   Methods: Our samples included 200 unrelated patients diagnosed with Schizophrenia   on the basis of DSM-IV criteria an...

Background and objectives: Rheumatoid arthritis (RA) is an autoimmune disease with a complex genetic background. The protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a lymphoid specific protein tyrosine phosphatase which is involved in negative regulation of T cell response. Several studies have assessed the association between PTPN22 single nucleotide polymorphisms (SNPs) with RA ...

Background: Single nucleotide polymorphisms (SNPs) in the promoter region of miRNAs may disturb miRNAs processing, alter their expression, and ultimately affect an individual’s susceptibility to cancer. We conducted a case-control study to evaluate the association of rs353293 G>A with the risk of thyroid cancer in the Iranian population. Methods: 192 patients with thyroid cancer including (pap...

Type 2 Diabetes Mellitus (T2D) is the most common metabolic disease demonstrating itself by hyper- glycemia, due to impaired insulin secretion or action. Recently, Whole-Genome Association studies have revealed the role of several new genes responsible for T2D. One of the most studied genes is SLC30A8 (Zn-T8) which is exclusively expressed in pancreatic ?-cells and participates in insulin stora...

A patient with infectious mononucleosis complicated by acute haemolytic anaemia is described. The patient had, in addition to non-specific cold agglutinins in the serum, a positive Donath-Landsteiner reaction in the absence of syphilis. The association of a positive Donath-Landsteiner reaction with haemolytic anaemia in infectious mononucleosis has been described only once before.

abstract   background: the disrupted-in-schizophrenia 1 (disc1) gene, on the chromosome position 1q42, was initially identified at the breakpoint of a balanced translocation, t(1,11)(q42.1q14.3), which segregated with major mental disorders in a large scottish family.   methods: our samples included 200 unrelated patients diagnosed with schizophrenia on the basis of dsm-iv criteria and 200 norm...

background inflammatory bowel disease (ibd) is a chronic, relapsing, inflammatory disorder of the gastrointestinal tract that includes two entities, crohn`s disease (cd) and ulcerative colitis (uc). as with other complex diseases, both genetic susceptibility and environmental factors play role in the pathogenesis of these diseases. the tumor necrosis factor α (tnf-α) gene is located in the ibd3...

the objective of this study was to determine the polymorphism of bovine β-lactoglobulin (β-lg) gene and its association with milk production traits in iranian najdi cattle. blood samples were collected from 80 najdi cattle from the najdi cattle breeding station located in shoshtar, khuzestan. polymerase chain reaction (pcr) and restriction fragment length polymorphism (rflp) techniqus were used...

nitric oxide is an important vasorelaxant factor that it inhibits platelet adhesion and proliferation of smooth muscle cells. no is synthesized from l-arginine by means of endothelial nitric oxide synthase (enos) which is an isoform of  nitric oxide synthase.in the present study, we examined  possible association between the 27 base pair (bp) repeat  polymorphism in intron 4 of the  enos3 gene ...

OBJECTIVE: Oral manifestations in diabetic patients can have different causes. Possibly, one of these causes is salivary glucose. The aim of this study was to evaluate salivary glucose concentrations in patients with Type II diabetes mellitus (DM) and their association with oral and dental manifestations and compare them with normal adults. MATERIALS AND METHODS: In this analytical study, 128 p...