1 Doutor em Medicina Otorrinolaringologia (Professor adjunto e Chefe do Serviço de Otorrinolaringologia, Hospital das Clínicas, Universidade Federal de Goiás). 2 Doutora em Ciências da Saúde. (Fonoaudióloga Epidemiologista. Serviço de Otorrinolaringologia, Hospital das Clínicas, Universidade Federal de Goiás, Goiânia, GO). 3 Otorrinolaringologista. (Médica otorrinolaringologista. Hospital das C...

The pathological findings in three cases of equine phycomycosis in Costa Rica are described. Two cutaneous (Pythium sp) and one nasal lesion (Conidiobolus) were observed.

OBJECTIVES/HYPOTHESIS To evaluate vocal outcomes in 10 patients 1 year after autologous transplantation of temporalis fascia into Reinke's space (ATFV) for vocal fold scar and sulcus vocalis. STUDY DESIGN Retrospective, clinical case series. METHODS Subjective and objective evaluation was performed 12 months after surgery using laryngovideostroboscopy (LVS) in all patients, the Voice Handic...

INTRODUCTION Primary adrenal insufficiency (PAI) is a rare but severe and potentially life-threatening condition. No previous studies have characterized Portuguese patients with PAI. AIMS To characterize the clinical presentation, diagnostic workup, treatment and follow-up of Portuguese patients with confirmed PAI. METHODS This multicentre retrospective study examined PAI patients in 12 Por...

INTRODUCTION The need to detect pancreatic cancer at earlier stages is undisputed. We recorded the signs and symptoms of patients presenting with exocrine pancreatic cancer and evaluated their association with clinical characteristics such as tumour site and disease stage. PATIENTS AND METHODS All patients (n = 185) with exocrine pancreatic cancer newly diagnosed at five general hospitals in ...

BACKGROUND: Patients in general hospitals often display concomitant signs of mental maladjustment: low mood, anxiety, apathy, asthenia, all which can have a negative impact on the course underlying disease and recovery process. One non-pharmacological approaches that has gained wider acceptance medical practice recent years is use procedures based virtual reality.
 AIM: Assess efficacy new...

BACKGROUND Sunitinib has shown single-agent activity in patients with previously treated metastatic breast cancer (MBC). We investigated the safety of the combination of sunitinib and paclitaxel in an exploratory study of patients with locally advanced or MBC. METHODS Patients received oral sunitinib 25 mg/day (with escalation to 37.5 mg/day as tolerated) on a continuous daily dosing schedule...

Coronary artery disease (CAD) is the leading causes of deaths in the world. The differentiation of syndrome (ZHENG) is the criterion of diagnosis and therapeutic in TCM. Therefore, syndrome prediction in silico can be improving the performance of treatment. In this paper, we present a Bayesian network framework to construct a high-confidence syndrome predictor based on the optimum subset, that ...

AIMS OF THE STUDY Asthenic symptoms such as weakness accompany illness. This study investigates whether the centrally acting cholinergic agent, vitamin B analogue (sulbutiamine), is effective and acceptable in relieving these symptoms in infectious disease when combined with specific anti-infective treatment. METHODOLOGY In a prospective uncontrolled, non-randomised, commercial, observational...

Cetuximab is a chimeric monoclonal antibody highly selective for the epidermal growth factor receptor (EGFR), which is over-expressed by 25-80% of colorectal cancer tumours and associated with advanced disease. Cetuximab induces a broad range of cellular responses in tumours expressing EGFR, enhancing sensitivity to radiotherapy and chemotherapeutic agents. In a large, randomised, open-label, m...