background: asthma is a chronic inflammatory disease with multifactorial and complicated mechanisms. elevated level of exhaled nitric oxide (no) in asthma and other inflammatory lung diseases has led to many studies examining no as a potential marker of airway inflammation. objective: this study was designed to determine the level of no in bronchoalveolar lavage (bal) fluid during early and lat...

are more effective asthma-controller medications compared with montelukast in children older than 6 years. Although this study failed to show statistical significance in the primary outcome, it provides data supporting certain treatment benefits of ICSs in children younger than 6 years (257 of 395 children were 5 years old). Compared with previous studies, these children had milder asthma, with...

We report the case of a 14-month-old girl suffering from cough and wheeze around Christmas. She was treated with anti-asthmatic drugs with no success, and 3 weeks later a chest X-ray revealed a LED bulb in the left main bronchus. This LED bulb came from a Christmas light garland decorating the Christmas tree. We discuss the different Christmas objects that can be inhaled by young children, the ...

The combined effect of oral nifedipine and aerosolized sodium cromoglycate on the airway response to inhaled sodium chloride at increasing concentrations was randomly studied in 10 patients with bronchial asthma. Nifedipine (20 mg) protected the airways in 6 of the 10 patients, and sodium cromoglycate (20 mg) in all the 10 patients. Following both drugs, the airway response to hypertonic saline...

It is presumed that drugs able to prevent bronchial spasm and/or inflammation may have therapeutic potential to control asthma symptoms. The local anaesthetic lidocaine has recently received increased attention as an alternative form of treatment for asthmatic patients. This paper reviews the major findings on the topic and summarizes the putative mechanisms underlying the airway effects of loc...

I. The protective effect of different particle sizes of sodium cromoglycate (SCG) was assessed by exercise challenge in nine asthmatic patients. 2. SCG particles of 11.7 pm or 2 0 pm mass median diameter were generated by a spinning disc and compared with lactose placebo particles. The drugs were given 10 min before a 6 min run on a treadmill. 3. The post-exercise bronchoconstriction caused a 4...

Several bronchodilator drugs commonly used in respiratory therapy contain sodium metabisulfite as an antioxidant preservative. When aerosolized, these agents may release the irritant gas SO2 as a result of bisulfite decomposition. We found that agents that contain bisulfites generated SO2 concentrations of 2.0 ppm and greater, while bronchodilator solutions without bisulfite did not. Such level...

l eukotriene receptor antagonists have been used successfully for asthma treatment. These drugs could induce eosinophilic granulomatosis with polyangiitis (EGPA), previously known as Churg-Strauss syndrome (CSS), in patients who are prone to develop autoimmune diseases [1] One of the most important adjuvants responsible for developing ASIA (autoimmune/ inflammatory syndrome induced by adjuvants...

Allergic diseases such as bronchial asthma and atopic dermatitis develop by a combination of genetic and environmental factors. Several candidate causative genes of asthma and atopy have been reported as the genetic factors. The clinical features of patients and causes of diseases vary. Therefore, personalized medicine (tailor-made medicine) is necessary for the improvement of quality of life (...