A comprehensive investigation on the hot-carrier-induced interface state generation and its impact carrier mobility in nMOSFET is performed. I- V compact modeling charge pumping (CP) characterization are used as independent ways to evaluate density a function of aging. From two techniques, similar power-law time exponents kinetics obtained. Assisted by quasi-spectroscopic (temperature-resolved)...

BACKGROUND Machado-Joseph disease (MJD), also named spinocerebellar ataxia type 3 (SCA3) is the most common autosomal dominant ataxia worldwide. Although nystagmus is one of the most frequently reported ocular alterations in MJD patients its behaviour during the course of the disease, namely in its early stages, has only recently started to be investigated. The main goal of this work was to cha...

Therapeutic targets are needed to develop neuroprotective treatments for Parkinson's disease (PD). Mitophagy, the selective autophagic elimination of dysfunctional mitochondria, is essential for the maintenance of mitochondrial integrity and is predominantly regulated by the PINK1/Parkin-mediated pathway. Loss of function mutations in Parkin and PINK1 cause an accumulation of dysfunctional mito...

UNLABELLED The pathogenesis of persistent foot-and-mouth disease virus (FMDV) infection was investigated in 46 cattle that were either naive or had been vaccinated using a recombinant, adenovirus-vectored vaccine 2 weeks before challenge. The prevalence of FMDV persistence was similar in both groups (62% in vaccinated cattle, 67% in nonvaccinated cattle), despite vaccinated cattle having been p...

CONTEXT The geographical distributions of hemoglobin S (HbS), hemoglobin C (HbC), and alpha+-thalassemia (-alpha) strongly suggest balancing selection with malaria. However, whereas several studies indicate that the HbS carrier state protects against all major forms of clinical malaria, malaria protection on clinical grounds has been more difficult to confirm for HbC and -alpha, and questions r...

BACKGROUND To investigate the risk of hepatitis B virus (HBV) reactivation in rheumatoid arthritis (RA) patients with HBV carrier state during treatment of disease-modifying antirheumatic drugs (DMARDs) and the use of antiviral prophylaxis in real-world clinical practice. METHODS Consecutive RA patients with HBV carrier state were included. Clinical data including liver evaluation, HBV infect...

The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). clinical manifestation COVID-19 is broad, ranging from an asymptomatic carrier state to leading death penalty. There also emerging evidence that kidneys are affected early in COVID-19. Proteinuria and haematuria have been reported 44% 26.7% on admission, respectively. ...