نتایج جستجو برای: asymptomatic malaria

تعداد نتایج: 95749  

2016
Jacob B. Aguilar Juan B. Gutierrez

Abstract. Asymptomatic individuals in the context of malarial disease refers to subjects who carry a parasite load but do not show clinical symptoms. A correct understanding of the influence of asymptomatic individuals on transmission dynamics will provide a comprehensive description of the complex interplay between the definitive host (femaleAnopheles mosquito), intermediate host (human) and a...

Journal: :Journal of research in health sciences 2012
Frederick Olusegun Akinbo Richard Omoregie

BACKGROUND Plasmodium falciparum infection is endemic in most tropical countries and will definitely infect Human Immunodeficiency Virus (HIV) positive patients living in this region at one time or the other during the course of their infection. This study was conducted to determine the prevalence of malaria infection in HIV-infected patients on highly active antiretroviral therapy in Benin Cit...

2017
Chris J. Drakeley Gillian Stresman

Artemisinin and partner drug-resistant falciparum malaria is Background: expanding over the Greater Mekong Sub-region (GMS). Eliminating falciparum malaria in the GMS while drugs still retain enough efficacy could prevent global spread of antimalarial resistance. Eliminating malaria rapidly requires targeting the reservoir of asymptomatic parasite carriers. This pilot trial aimed to evaluate th...

2012
Simone da Silva Santos Taane G. Clark Susana Campino Martha Cecília Suarez-Mutis Kirk A. Rockett Dominic P. Kwiatkowski Octavio Fernandes

The Brazilian Amazon is a hypo-endemic malaria region with nearly 300,000 cases each year. A variety of genetic polymorphisms, particularly in erythrocyte receptors and immune response related genes, have been described to be associated with susceptibility and resistance to malaria. In order to identify polymorphisms that might be associated with malaria clinical outcomes in a Brazilian Amazoni...

2016
Lauren E Holz Daniel Fernandez-Ruiz William R Heath

Despite decades of research and recent clinical trials, an efficacious long-lasting preventative vaccine for malaria remains elusive. This parasite infects mammals via mosquito bites, progressing through several stages including the relatively short asymptomatic liver stage followed by the more persistent cyclic blood stage, the latter of which is responsible for all disease symptoms. As the li...

2017
Jordi Landier Ladda Kajeechiwa May Myo Thwin Daniel M Parker Victor Chaumeau Jacher Wiladphaingern Mallika Imwong Olivo Miotto Krittaya Patumrat Jureeporn Duanguppama Dominique Cerqueira Benoit Malleret Laurent Rénia Suphak Nosten Lorenz von Seidlein Clare Ling Stéphane Proux Vincent Corbel Julie A Simpson Arjen M Dondorp Nicholas J White François H Nosten

Background: Artemisinin and partner drug-resistant falciparum malaria is expanding over the Greater Mekong Sub-region (GMS). Eliminating falciparum malaria in the GMS while drugs still retain enough efficacy could prevent global spread of antimalarial resistance. Eliminating malaria rapidly requires targeting the reservoir of asymptomatic parasite carriers. This pilot trial aimed to evaluate th...

2017
Gregory S Park Robert O Opoka Estela Shabani Alexis Wypyszynski Benjamin Hanisch Chandy C John

BACKGROUND Malaria retinopathy has been proposed as marker of "true" cerebral malaria (CM), ie, coma due to Plasmodium falciparum vs coma due to other causes, with incidental P falciparum parasitemia. Plasma P falciparum histidine-rich protein-2 (PfHRP2) concentrations distinguish retinopathy-positive (RP) from retinopathy-negative (RN) CM but have not been compared between RN CM and other form...

2014
Alessandra Sampaio Bassi Fratus Fernanda Janku Cabral Wesley Luzetti Fotoran Márcia Melo Medeiros Bianca Cechetto Carlos Rosimeire dalla Martha Luiz Hildebrando Pereira da Silva Stefanie Costa Pinto Lopes Fabio Trindade Maranhão Costa Gerhard Wunderlich

In the Amazon Region, there is a virtual absence of severe malaria and few fatal cases of naturally occurring Plasmodium falciparum infections; this presents an intriguing and underexplored area of research. In addition to the rapid access of infected persons to effective treatment, one cause of this phenomenon might be the recognition of cytoadherent variant proteins on the infected red blood ...

Journal: :Evidence-based medicine 2015
Geoffrey Targett

Context There is currently no licensed malaria vaccine. Protection against malaria is dependent on use of insecticide-treated nets, other vector control measures and drug treatment. These have reduced the burden of disease over the past decade, but it remains unacceptably high. Malaria transmission is heterogeneous and there are particular challenges presented by hotspots of transmission and by...

Journal: :PLoS Biology 2005
Sandra Incardona Sirenda Vong Lim Chiv Pharath Lim Sina Nhem Rithy Sem Nimol Khim Socheat Doung Odile Mercereau-Puijalon Thierry Fandeur

Background: In Cambodia, estimates of the malaria burden rely on a public health information system that does not record cases occurring among remote populations, neither malaria cases treated in the private sector nor asymptomatic carriers. A global estimate of the current malaria situation and associated risk factors is, therefore, still lacking. Methods: A large cross-sectional survey was ca...

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