An algorithm for detecting local clusters of homologous genes was applied to the genome of Caenorhabditis elegans. Clusters of two or more homologous genes are abundant, totaling 1391 clusters containing 4607 genes, over one-fifth of all genes in C. elegans. Cluster genes are distributed unevenly in the genome, with the large majority located on autosomal chromosome arms, regions characterized ...

BACKGROUND The overall objective of the Ansan Geriatric Study (AGE study) was to describe the prevalence, incidence, and related risk factors for geriatric diseases in elderly Koreans. METHODS/DESIGN The AGE study was designed as a population-based prospective cohort study on health, aging, and common geriatric diseases of elderly Koreans aged 60 to 84 years. The inception cohort was recruite...

"Cochlea wave propagation...” These words started off David Kemp's seminal 1978 contribution to auditory biophysics, where he first described "a new auditory phenomenon” [JASA 64(5): 1386-1391]. The impact of this report has transcended numerous disciplines, finding an impressive range of scientific and clinical applications (e.g., monitoring cochlear status to ototoxicity, biophysical models o...

BACKGROUND Dyslipidemia after kidney transplantation is a frequent finding and is multifactorial. Immunosuppressive agents such as cyclosporine (CsA) can cause hypercholesterolemia. OBJECTIVES As there were few reports with conflicting evidence on whether CsA related dyslipidemia is dose related and that CsA monitoring assays (trough level, C0, or two hour post dose level, C2) is a better pre...

OBJECTIVE In this study, we aimed to detect the incidences of ototoxicity in patients with hemoglobinopathies taking deferoxamine (DFO), deferiprone, and deferasirox using the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) scale to obtain more objective data. MATERIALS AND METHODS Fifty-five transfusion-dependent patients were evaluated in this study. T...

Abstract Objective: To identify regional cerebral blood flow (rCBF) differences among children with varying Attention-deficit/hyperactivity disorder (ADHD) subtypes. The participants were part of an archival de-identified database that received SPECT scans at baseline. sample (N= 3222) consisted ADHD classifications asymptomatic (N=773), combined type (N=1157), hyperactive (N=25), inattentive (...

This article advocates workplace adult education and training researchers and scholar practitioners interested in career and technical education (CTE), adult education and technology, and who are attempting social and cultural critiques of workplace e-learning. The emphasis on the technological and artefactual in workplace e-learning research and study are not producing the expected learning ou...

This article deals with the Value at Risk concept as it is used in practice. We show that, like the Gaussian distribution, elliptical distributions lend themselves to simple practical computations. All necessary computations are detailed for the symmetric hyperbolic distributions. A test on real stock market and exchange rate data shows the new distributions fit the data better and outperform e...

Özetçe. Günümüz şirketleri, müşterilerinin beklentilerini anlamak ve bu beklentilere hızlı ve doğru bir şekilde tepki vermek durumundadır. Artık, bilişim sistemleri karar destek sistemleri olmaktan çıkmış ve doğrudan yönetimin, üretimin, ticaretin ve sosyal hayatın yaşandığı sistemler haline gelmiştir. Hayatın kendisini beklemeye almak hayattan kopuş ile sonuçlanmaktadır. Uygulama yazılımları i...