Apraxia of speech is a disorder of speech motor planning and/or programming that is distinguishable from aphasia and dysarthria. It most commonly results from vascular insults but can occur in degenerative diseases where it has typically been subsumed under aphasia, or it occurs in the context of more widespread neurodegeneration. The aim of this study was to determine whether apraxia of speech...

background: ataxia telangiectasia (at) is one of the combined immunodeficiency syndromes with immunologic, neurologic, endocrinologic, hepatic and cutaneous abnormalities. regarding the fact that autoimmune disorders; such as autoimmune hemolytic anemia (aiha), are not generally expected in the course of at, we present a patient with an unusual presentation of these two conditions. case present...

This corrects the article on p. 126 in vol. 12, PMID: 26541496.

Motor apraxia was assessed in 25 patients with presumed dementia of the Alzheimer type and 23 patients with presumed multi-infarct dementia. Apraxia was common in both groups and was usually only mild. It correlated most strongly with language-related impairments in the Alzheimer group, as has been found in other patient groups, whereas in the group with multi-infarct dementia the pattern of co...

BACKGROUND Downbeat nystagmus (DBN) is a common form of acquired fixation nystagmus with key symptoms of oscillopsia and gait disturbance. Gait disturbance could be a result of impaired visual feedback due to the involuntary ocular oscillations. Alternatively, a malfunction of cerebellar locomotor control might be involved, since DBN is considered a vestibulocerebellar disorder. METHODS Inves...

Ataxia oculomotor apraxia-1 is a neurological disorder that arises from mutations in the gene encoding the protein aprataxin. A recent study demonstrates that aprataxin is critical for the processing of obstructive DNA termini, suggesting a broader role for DNA single-strand break repair in neurodegenerative disease.