The aim of this study was to gain better insight into molecular changes which reflect disturbances in the balance between proliferation and apoptosis during progression of thyroid malignancy from papillary microcarcinoma (PMC) via clinically manifest papillary carcinoma (PTC) to anaplastic carcinoma (ATC). The apoptosis related molecules (Bcl-2, Bax) and proliferation related marker (PCNA) were...

Anaplastic thyroid cancer (ATC) is among the most lethal types of cancers, characterized as a fast-growing and highly invasive thyroid tumor that is unresponsive to surgery and radioiodine, blunting therapeutic efficacy. Classically, genetic alterations in tumor suppressor TP53 are frequent, and cumulative alterations in different signaling pathways, such as MAPK and PI3K, are detected in ATC. ...

Here, we show that the anaplastic thyroid carcinoma (ATC) features the up-regulation of a set of genes involved in the control of cell cycle progression and chromosome segregation. This phenotype differentiates ATC from normal tissue and from well-differentiated papillary thyroid carcinoma. Transcriptional promoters of the ATC up-regulated genes are characterized by a modular organization featu...

BACKGROUND Anaplastic thyroid cancer (ATC) is a rare, lethal disease associated with a median survival of 6 months despite the best multidisciplinary care. Surgical resection is not curative in ATC patients, being often a palliative procedure. Multidisciplinary care may include surgery, loco-regional radiotherapy, and systemic therapy. Besides conventional chemotherapy, multi kinase-targeted in...

BACKGROUND Anaplastic thyroid carcinoma (ATC) is an uncommon thyroid malignancy with a poor prognosis. American Thyroid Association (ATA) guidelines acknowledge the complexity of airway management in these patients. We studied our local experience with the aim of providing guidance in airway management in ATC. METHODS Patients with histologically confirmed ATC from January 2004 to December 20...

Electric power industries throughout the world have been restructured to introduce competition among the market participants and bring several competitive opportunities. Open access to the transmission system places an emphasis on the intensive use of the interconnected network reliably, which requires knowledge of the network capability. Available Transfer Capability (ATC) is a measure of the ...

Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human cancers. Actually, ATC is refractory to conventional therapies, including surgery, chemotherapy, radiotherapy, and radioiodine ((131)I) therapy. Accordingly, genetic and molecular characterizations of ATC have been frequently and periodically reviewed in order to identify potential biological markers exploitable for target t...

(RCS) frames which are systems that dwell of concrete columns and steel beams , by optimizing the act of compressive strength of concrete and bending strength of steel due to not only a decrease in building weight in comparison to concrete structures but also having a better action in long spans frames . In this paper for analysis RCS behavior, a category of nonlinear Push Over analyses were ...

To the Editor: In “Collision tumors of the thyroid: A case report and review of the literature,” Ryan et al describe an interesting case of an 88-year-old woman with airway compromise because of a thyroid mass. This patient also had widespread metastases on presentation. Surgical pathology demonstrated a papillary thyroid carcinoma and a squamous cell carcinoma. This case is a common scenario t...

cent initiatives involving social psychology applications in the aviation world have redoubled the interest in ept of teams and teamwork. The importance of teamwork in airline cockpits, hailed as cockpit (or crew-) management (CRM), has been recognized for a relatively long time. It is also widely agreed that extensive ctive interaction among participants in the National Airspace System (NAS), ...