BACKGROUND Accurate alignment between histopathology slices and positron emission tomography (PET) images is important for radiopharmaceutical validation studies. Limited data is available on the registration accuracy that can be achieved between PET and histopathology slices acquired under routine pathology conditions where slices may be non-parallel, non-contiguously cut and of standard block...

This paper explores the structural differences and relative goodness-of-fits of affine term structure models (ATSMs). Within the family of ATSMs there is a tradeoff between flexibility in modeling the conditional correlations and volatilities of the risk factors. This trade-off is formalized by our classification of N-factor affine family into N + 1 non-nested subfamilies of models. Specializin...

Tuberculosis is caused by Mycobacterium tuberculosis (Mtb) infection. Mtb is one of the oldest human pathogens, and evolves mechanisms implied in human evolution. The lungs are the first organ exposed to aerosol-transmitted Mtb during gaseous exchange. Therefore, the guards of the immune system in the lungs, such as macrophages (Mϕs) and dendritic cells (DCs), are the most important defense aga...

BACKGROUND Preclinical imaging requires anaesthesia to reduce motion-related artefacts. For direct translational relevance, anaesthesia must not significantly alter experimental outcome. This study reports on the effects of both anaesthetic and carrier gas upon the uptake of [⁶⁴Cu]-CuATSM, [(⁹⁹m)Tc]-HL91 and [¹⁸F]-FMISO in a preclinical model of tumor hypoxia. METHODOLOGY/PRINCIPAL FINDINGS T...

Blaine R. Roberts,1* Nastasia K. H. Lim,2* Erin J. McAllum,2* Paul S. Donnelly,3,4 Dominic J. Hare,1,6 Philip A. Doble,6 Bradley J. Turner,1 Katherine A. Price,2 Sin Chun Lim,3,4 Brett M. Paterson,3,4 James L. Hickey,3,4 Timothy W. Rhoads,7,8 Jared R. Williams,7,8 Katja M. Kanninen,2 Lin W. Hung,1,4 Jeffrey R. Liddell,2 Alexandra Grubman,2 Jean-Francois Monty,10 Roxana M. Llanos,10 David R. Kra...

In this paper, we characterize, interpret, and test the over-identifying restrictions imposed in a ne models of the term-structure. "We begin by showing, using the classi cation scheme proposed by Dai, Liu, and Singleton [10] for general a ne di usions, that the family of N -factor models can be classi ed into N + 1 non-nested sub-families of models. For each subfamily, we derive a canonical mo...

-Compost filter socks are generally used to control sediment on construction sites or land disturbing activities. Higher sediment removal efficiencies of compost filter socks, relative to silt fence, have been attributed to its larger surface area and sediment storage capacity, due to its tubular construction. Compost has been used widely to bioremediate polluted soils. By adding new materials ...