The mammalian auditory system is sensitive to genetic disorders, aging and injuries caused by overstimulation, ototoxic drugs and viral infections. Since the sensory epithelium (the organ of Corti) and the spiral ganglion neurons (SGNs) in adult mammalian do not regenerate spontaneously when they are damaged, a cell substitution strategy was proposed to compensate the function of the degenerate...

traumatic brain injury (tbi) is defined as an external mechanical injury to the brain. neuroinflammation plays a vital role in the pathophysiology of tbi. microglia and astrocytes play a central role in the initiation and regulation of inflammation. numerous pro-inflammatory mediators including cytokines, chemokines, reactive oxygen species (ros) and nitric oxide (no) released by microglia. in ...

Speech delay with an unknown cause is a problem among children. This diagnosis is the last differential diagnosis after observing normal findings in routine hearing tests. The present study was undertaken to determine whether auditory brainstem responses to click stimuli are different between normally developing children and children suffering from delayed speech with unknown causes. In this cr...

To examine the influence of acoustic experience on the development of the mammalian auditory brain stem, darkly pigmented ferrets were reared with a plug inserted in the right outer ear. The plugs were first inserted on postnatal day 23-34 and produced a variable, frequency-dependent attenuation of up to 60 dB. Between 3-15 months after the ear plug was begun, animals were prepared for physiolo...

Introduction: The world community is concerned with the assessment of speech and hearing development children sensorineural deafness after cochlear implantation, since most important result rehabilitation success social integration such children. In countries world, Meaningful Auditory Integration Scale (MAIS) Use Language (MUSS) are used to assess auditory language loss implantation (CI). Unfo...

intractable hiccup most be considered as a symptom of underlying serious pathologies. we report a case of medulla oblongata cavernous angima presented with persistant hiccup and without any improvement during routine nonpharmacologic and pharmacologic treatment regimns. the patient is under our follow up visits and surgery is very high risk for this young girl.

Many studies, using a variety of imaging techniques, have shown that deafness induces functional plasticity in the brain of adults with late-onset deafness, and in children changes the way the auditory brain develops. Cross modal plasticity refers to evidence that stimuli of one modality (e.g. vision) activate neural regions devoted to a different modality (e.g. hearing) that are not normally a...

Background: Tinnitus known as a central nervous system disorder is correlated with specific oscillatory activities within auditory and non-auditory brain areas. Several studies in the past few years have revealed that in the most tinnitus cases, the response pattern of neurons in auditory system is changed due to auditory deafferentation, which leads to variation and disruption of the brain net...

Short-term synaptic plasticity (STP) acts as a time- and firing rate-dependent filter that mediates the transmission of information across synapses. In the auditory brain stem, the divergent pathways that encode acoustic timing and intensity information express differential STP. To investigate what factors determine the plasticity expressed at different terminals, we tested whether presynaptic ...

8/1/12 1:18 AM 1 2 3 Intrinsic firing properties in the avian auditory brain stem allow both integration and 4 encoding of temporally modulated noisy inputs in vitro 5 6 Lauren J. Kreeger, Arslaan Arshed and Katrina M. MacLeod 7 8 9 10 11 12 13 14 Author contributions: Experiments were designed, carried out and analyzed by LJK, AA and KMM. 15 Manuscript was written primarily by KMM, with assist...