OBJECTIVE To confirm syntaxin 1A as a risk factor for migraine, given that syntaxin 1A interacts with several factors in migraine pathophysiology. DESIGN Case-control approach. SETTING An outpatient clinic. PARTICIPANTS In a sample of 188 migraineurs (111 without aura and 77 with aura) and 287 migraine-free controls, 3 tagging SNPs of STX1A (rs3793243, rs941298, and rs6951030) were analyz...

OBJECTIVES To investigate visual function in migraine using visual evoked potentials. METHODS Electroretinograms (ERGs) and visual evoked potentials (VEPs) to single flash (SF) and pattern reversal (PR) stimuli were studied in 92 migraine subjects and 62 controls. RESULTS In subjects with migraine, ERGs to single flash were normal. Mean latencies of the P1 and P2 waves in the SFVEP were inc...

Dr. Deusvenir de Souza-Carvalho – Rua Pedro de Toledo 980 / 33 04039-002 São Paulo SP Brasil. E-mail: [email protected] According to the second edition of the International Classification of Headache Disorders (ICHD-II), migrainous infarction (MI) is a complication of migraine with aura. MI is diagnosed when one or more aura symptoms last longer than 60 minutes, and neuroradiological stud...

In contrast to patent foramen ovale that is highly prevalent in the general population, atrial septal defect (ASD) is a rare congenital heart defect. The effect of ASD closure on headache and migraine remains a matter of controversy. The objectives of our study were (1) to determine headache prevalence in consecutive patients with ASD scheduled for percutaneous closure for cardiologic indicatio...

BACKGROUND Migraine is recognised increasingly as a risk factor for ischaemic stroke in women of childbearing age. Migraine with aura poses a higher risk than migraine without aura. OBJECTIVE To investigate further the effect of duration, frequency, recency, and type of migraine on the risk of ischaemic stroke. METHODS Additional analyses of a previously reported multicentre case-control st...

BACKGROUND AND PURPOSE Migraine is a risk factor for clinical stroke and for subclinical white matter hyperintensities and infratentorial infarcts. These subclinical lesions are linked to small-vessel pathology. Cerebral microbleeds (CMBs) are another biomarker of small-vessel disease but have not yet been studied in migraine. METHODS Identification of CMBs in 63 migraineurs (25 with aura/35 ...