BACKGROUND AND PURPOSE It has been suggested that avascular osteonecrosis (AVN) of the femoral head occurs early after systemic steroid administration. The purpose of this study was to investigate the risks regarding development of AVN at a very early stage after renal transplantation. METHODS The presence or absence of AVN was determined by MRI at 4 weeks, at 6-12 weeks, at 24 weeks, and at ...

The authors have retrospectively studied the results achieved with the AO/ASIF PFN system in the treatment of unstable intertrochanteric fractures of the proximal femur. Between June 1999 and February 2003, 51 patients with unstable intertrochanteric fractures of the proximal femur underwent intramedullary nailing with the PFN system. A total of 45 patients (28 women, 17 men, average age 72 yea...

A 11 year old boy was brought to the accident and emergency department with a painful left hip after having been injured it in a tackle in a casual game of rugby. On examination the hip was found to be flexed, adducted and internally rotated with no distal neurovascular deficit. All movements of that hip were extremely painful. Posterior dislocation of hip was confirmed by radiograph (fig 1).Th...

Osteonecrosis or avascular necrosis (AVN) of the hip is a progressive disease mainly affecting adults in their third, fourth or fifth decade of life. Studies into the natural history of the disease suggest that femoral head collapse occurs within 2-3 yrs with associated degenerative changes and at that stage arthroplasty is the most reliable treatment option. Therefore prevention of femoral hea...

BACKGROUND Thrombophilia has been implicated in the development of avascular necrosis (AVN) in various diseases. We aimed to search for the relation of both prothrombin gene G20210A mutation and factor V G1691A (factor V Leiden) mutation with AVN among kidney transplant recipients. METHODS Nineteen patients with AVN and 38 control patients without AVN were included. Clinical information was c...

Objective. The aim of this study was to investigate the extent of placental lesions associated with blood pressure (BP) levels in pregnancies complicated by hypertension. Methods. 55 singleton pregnancies complicated by mild hypertension were recruited and compared to 55 pregnancies complicated by severe hypertension. The histological assessment was carried out with regard to the following aspe...

BACKGROUND Tumour necrosis factor antagonists (anti-TNF-α) have demonstrated the efficacy in different chronic immune inflammatory disorders. Within the spectrum of adverse events, autoimmune diseases have been observed, including cases of alopecia areata (AA). OBJECTIVES The objective of the study is to characterize AA developed during anti-TNF-α therapy. METHODS We present five new cases ...

Obesity is a risk factor for ischemic necrosis of the femoral head (INFH). The purpose of this study was to determine if leptin treatment of INFH stimulates new bone formation to preserve femoral head shape in rats with diet-induced obesity. Rats were fed a high-fat diet (HFD) or normal chow diet (NCD) for 16 weeks to induce progressive development of obesity. Avascular necrosis of the femoral ...