Purpose: To describe the long-term outcomes of 2 cases primary autologous stem cell transplantation (ASCT) for treatment central nervous system lymphoma–ophthalmic variant (PCNSL-O) or vitreoretinal lymphoma (PVRL). Methods: Two and their findings were analyzed. A review histopathology, systemic treatment, multimodal ocular imaging was performed. Results: 52-year-old woman 56-year-old referred ...

BACKGROUND Epigenetic changes are involved in the extinction of the B-cell gene expression program of classical Hodgkin's lymphoma. However, little is known regarding epigenetic similarities between cells of classical Hodgkin's lymphoma and plasma cell myeloma, both of which share extinction of the gene expression program of mature B cells. DESIGN AND METHODS Global histone H3 acetylation pat...

BCL-6 mutations are accumulated during B-cell transit through the germinal center (GC) and provide a histogenetic marker for B-cell tumors. On the basis of a comprehensive analysis of 308 B-cell neoplasms, we (1) expand the spectrum of tumors associated with BCL-6 mutations; (2) corroborate the notion that mutations cluster with GC and post-GC B-cell neoplasms; and (3) identify heterogeneous mu...

The overlapping features of malignant lymphomas create a diagnostic "grey zone" , and lead to the invention of "grey zone lymphomas". There are several major grey zone lymphomas: 1) Lymphomas with overlapping features of Hodgkin lymphoma and large B-cell lymphoma; 2) Lymphomas with overlapping features of Burkitt lymphoma and diffuse large B-cell lymphoma; 3) Lymphomas with overlapping features...

introduction: most b-cell malignancies are diagnosed based on morphologic and immunohistochemical criteria. some cases, however, still present a challenge for the pathologist to discriminate between reactive hyperplasia and neoplastic disorders. molecular techniques can be used as a helpful diagnostic tool in these cases. in this study, we assessed the value of polymerase chain reaction (pcr) t...

The group of marginal zone B-cell lymphomas (MZL) comprises three different entities, extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (currently called MALT lymphoma), nodal marginal zone B-cell lymphoma (previously known as monocytoid lymphoma), and splenic marginal zone B-cell lymphoma (with or without circulating villous lymphocytes).[1-3] Primary splenic and no...

The determination of prognosis for B-Non-Hodgkin's lymphoma (NHL) is known to be related to the multiple differences in tumor cell biology. Bcl-2 and Bcl-6 are two markers linked to germinal center B cells. Both markers are thought to have an effect on prognosis of mature B-cell neoplasms. Forty-four patients with chronic B-cell neoplasm were included; Bcl-2 and Bcl-6 expression by immunohistoc...