We seek to understand the link between protein thermodynamics and protein structure in molecular detail. A classical approach to this problem involves assessing changes in protein stability resulting from added cosolvents. Under any given conditions, protein molecules in aqueous buffer are in equilibrium between unfolded and folded states, U(nfolded) <==> N(ative). Addition of organic osmolytes...

We implemented molecular dynamics simulations of the 13-residue antimicrobial peptide indolicidin (ILPWKWPWWPWRR-NH2) in dodecylphosphocholine (DPC) and sodium dodecyl sulfate (SDS) micelles. In DPC, a persistent cation-pi interaction between TRP11 and ARG13 defined the structure of the peptide near the interface. A transient cation-pi interaction was also observed between TRP4 and the choline ...

Objective: In this paper, we have introduced topoisomerase inhibitors, mechanism of action and types of them. DNA topoisomerases are ubiquitous enzymes that catalyze essential enzymes to solve the topological problems accompanying key nuclear processes such as DNA replication, transcription, repair and chromatin assembly by introducing temporary single or double strand breaks in the DNA. Result...

Objective: In this paper, we have introduced topoisomerase inhibitors, mechanism of action and types of them. DNA topoisomerases are ubiquitous enzymes that catalyze essential enzymes to solve the topological problems accompanying key nuclear processes such as DNA replication, transcription, repair and chromatin assembly by introducing temporary single or double strand breaks in the DNA. Result...

tehran city has been subject of critical environmental challenges during the course of 20th. century namely: massive population growth, broad expansion, reduction in urban open/green spaces, increasing in energy consumption and waste production. releasing industrial wastewater into river valleys have led to considerable changes in structure of city&apos;s natural landscape. the natural structur...

In this work we study a peculiar example of social organization on Facebook: the Occupy Movement – i.e., an international protest movement against social and economic inequality organized online at a city level. We consider 179 US Facebook public pages during the time period between September 2011 and February 2013. The dataset includes 618K active users and 753K posts that received about 5.2M ...