Abstract Dysregulation of gene expression plays an important role in cancer development. Identifying transcriptional regulators, including transcription factors and chromatin that drive the oncogenic program is a critical task research. Genomic profiles active regulators from primary samples are limited public domain. Here we present BART Cancer (bartcancer.org), interactive web resource databa...

PATIENT Female, 70 FINAL DIAGNOSIS: Bile acid amino transferase deficiency Symptoms: Headache • indigestion • itching skin • nausea • vomiting MEDICATION - Clinical Procedure: - Specialty: Gastroenterology and Hepatology. OBJECTIVE Challenging differential diagnosis. BACKGROUND Bile acid synthesis impairments are difficult to diagnose due to non-specific manifestations related to progress...

The pathogenic lymphocryptovirus Epstein-Barr virus (EBV) is shown to express at least 17 distinct microRNAs (miRNAs) in latently infected cells. These are arranged in two clusters: 14 miRNAs are located in the introns of the viral BART gene while three are located adjacent to BHRF1. The BART miRNAs are expressed at high levels in latently infected epithelial cells and at lower, albeit detectab...

Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique used both experimentally and therapeutically to modulate regional brain function. However, few studies have directly measured the aftereffects of tDCS on brain activity or examined changes in task-related brain activity consequent to prefrontal tDCS. To investigate the neural effects of tDCS, we collecte...

Previous research suggests that sleep deprivation is associated with declines in metabolic activity within brain regions important for judgement and impulse control, yet previous studies have reported inconsistent findings regarding the effects of sleep loss and caffeine on risk-taking. In this study, 25 healthy adults (21 men, four women) completed the Balloon Analog Risk Task (BART) and Evalu...

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Beyond simply a decision process, repeated risky decisions also require a number of cognitive processes including learning, search and exploration, and attention. In this article, we examine how multiple response pathways develop over repeated risky decisions. Using the Balloon Analogue Risk Task (BART) as a case study, we show that 2 different response pathways emerge over the course of the ta...

Sequential risk-taking tasks, especially the Balloon Analogue Risk Task (BART), have proven powerful and useful methods in studying and identifying real-world risk takers. A natural index in these tasks is the average number of risks the participant takes in a trial (e.g., pumps on the balloons), but this is difficult to estimate because some trials terminate early because of the consequences o...

There are many different normative frameworks for describing service systems that take a distinct conceptual perspective. They emphasize the physical arrangement or topology, the functions or processes, the chronology of experience, the causality of value creation, the flow of information or people, or other characteristics. These frameworks are deeply embedded in service system research and de...

Latent infection of EBV is linked to the development of multiple cancers that have distinct patterns of expression of viral proteins and microRNAs (miRNAs). In this study, we show that in vitro infection of a gastric epithelial cell line with EBV alters growth properties and induces growth in soft agar. The infected cells have high levels of expression of a large cluster of viral miRNAs, [the B...