The basal and distal apical dendrites of pyramidal cells occupy distinct cortical layers and are targeted by axons originating in different cortical regions. Hence, apical and basal dendrites receive information from distinct sources. Physiological evidence suggests that this anatomically observed segregation of input sources may have functional significance. This possibility has been explored ...

Pyruvate carboxylase (PC) is an enzyme that plays a crucial role in many biosynthetic pathways in various tissues including glucose-stimulated insulin secretion. In the present study, we identify promoter usage of the human PC gene in pancreatic beta cells. The data show that in the human, two alternative promoters, proximal and distal, are responsible for the production of multiple mRNA isofor...

Synaptic plasticity rules widely determine how cortical networks develop and store information. Using confocal imaging and dual site focal synaptic stimulation, we show that basal dendrites, which receive the majority of synapses innervating neocortical pyramidal neurons, contain two compartments with respect to plasticity rules. Synapses innervating the proximal basal tree are easily modified ...

Mechanical properties of the skeleton four antipatharians (the whip species Cirrhipathes anguina and Stichopathes cf. maldivensis, branched Cupressopathes abies pumila) living in shallow waters off southwestern coast Madagascar were investigated using a three-point bending test. The Young's modulus did not differ according to but was significantly higher distal segment colonies, compared with b...

  Background: Considering the importance of an early diagnosis and proper decision-making in regards to the treatment of pediatric distal radius and elbow fractures, this study examines emergency medicine specialists’ accuracy in the diagnosis and treatment of these patients. Methods: From 2012 and 2013, children less than 14 years old who were referred to an academic hospital emergency departm...

Basal bodies organize cilia that are responsible for both mechanical beating and sensation. Nascent basal body assembly follows a series of well characterized morphological events; however, the proteins and their assembly dynamics for new basal body formation and function are not well understood. High-resolution light and electron microscopy studies were performed in Tetrahymena thermophila to ...

Given a digraph D = (V, A), a quasi-kernel of D is an independent set Q C_ V such that for every vertex v not contained in Q, either there exists a vertex u E Q such that v dominates u, or there exists a vertex w such that v dominates w and w dominates some vertex u E Q. A sink in a digraph D = (V, A) is a vertex v E V that dominates no vertex of D. In this thesis we prove that if D is a semico...

ROBERTS, JOHN S., AND BODIL SCHMIDT-NIELSEN. Renal ultrastructure and excretion of salt and water by three terrestrial lizards. Am. J. Physiol. 2 I I (1) : 476-486. I g66.-Determinations of sodium, chloride, inulin, and osmolal concentrations were made on blood and urine collected from dehydrated, waterloaded, and salt-loaded geckos, horned toads, and Galapagos lizards. Electron micrographs wer...

A new genus with a species of soft-winged flower beetle, Pectotibialis paghmanensis Tshernyshev gen. et sp. nov. are described from Afghanistan. The can be distinguished the congeners tribe Apalochrini by dark pectination in apices tibiae both sexes, and anterior which hollowed at distal half, flattened rounded femora, bituberculate basal parts head pronotum, two lamellate metathoracic appendag...

Atrial natriuretic peptide is an important peptide hormone of cardiac origin that functions to regulate cardiac preload via the regulation of sodium excretion. This natriuretic action occurs through activation of the particulate guanylyl cyclase-linked natriuretic peptide-A receptor. HS-142-1 is a newly discovered antagonist of the natriuretic peptide-A receptor that permits insight into the fu...