OBJECTIVE To investigate the pathogenic factors of severe acute pancreatitis (SAP) complicated by hepatic insufficiency, the prognosis and the effective preventive and therapeutic interventions. METHODS One hundred and fifty-two patients with SAP (from January 2003 to June 2004) were divided into 2 groups, SAP with hepatic insufficiency group and SAP without hepatic insufficiency group. The r...

1386 JEM Vol. 203, No. 6, 2006 Helpless without SAP CD4+ T cells that lack the adaptor protein SAP are little help to B cells, according to Cannons and colleagues on page 1551. But their unhelpful nature does not result from a failure to produce T helper (Th)-2 cytokines, as the authors had previously thought. The absence of SAP wreaks havoc on the immune system. SAP—the adaptor that links the ...

The human pathogen Staphylococcus aureus is responsible for many community-acquired and hospital-associated infections and is associated with high mortality. Concern over the emergence of multidrug-resistant strains has renewed interest in the elucidation of host mechanisms that defend against S. aureus infection. We recently demonstrated that human serum mannose-binding lectin binds to S. aure...

Scale insects (Hemiptera: Coccoidae) constitute a very diverse group of sap-feeding insects with a large diversity of symbiotic associations with bacteria. Here, we present the complete genome sequence, metabolic reconstruction, and comparative genomics of the flavobacterial endosymbiont of the giant scale insect Llaveia axin axin. The gene repertoire of its 309,299 bp genome was similar to tha...

This paper reports on first attempts to define, apply and fully integrate some reuse measurement practices into the SAP requirements engineering activities. It addresses all the facets of the context for SAP requirements reuse measurement and indicates who reuse metrics data are collected for, where and when during the RE process reuse measurements are made, what counting standards are appropri...

Science Activity Planner SAP is the primary science downlink analysis and uplink planning tool for NASA’s Mars Exploration Rover (MER) Mission. (http:// mars.jpl.nasa.gov/mer). During each sol (Martian day) of mission operations, scientists and engineers use SAP to visualize the data acquired by the rover on previous sols and develop a plan of activities for the rover to accomplish on the next ...

Signaling lymphocytic activation molecule-associated protein (SAP), an adaptor molecule that recruits Fyn to the signaling lymphocytic activation molecule (SLAM) family of immunomodulatory receptors, is mutated in X-linked lymphoproliferative disease. CD4(+) T cells from SAP-deficient mice have defective TCR-induced and follicular Th cell IL-4 production and impaired T cell-mediated help for ge...

PURPOSE To evaluate the effect of the anti-fibrotic protein serum amyloid P (SAP) on radiation-induced oral mucositis (OM) and fibrosis in a hamster cheek-pouch model. EXPERIMENTAL DESIGN Hamsters received a single dose of radiation (40 Gy) to the left everted cheek pouch to induce significant OM. The protective therapeutic potential of SAP was evaluated using varying dosing regimens. The ext...