BACKGROUND Sofosbuvir, an oral NS5B nucleotide polymerase inhibitor, is indicated for the treatment of patients infected with hepatitis C virus (HCV). AIM To evaluate the long-term health economic outcomes of sofosbuvir + pegylated interferon alfa/ribavirin (pegIFN/RBV) compared with current treatments in patients infected with HCV genotype 1 in the US. METHODS A decision-analytic Markov mo...

BACKGROUND Xerostomia is a common adverse event of unknown etiology observed during pegylated interferon (PegIFN)/Ribavirin (Rbv) treatment. OBJECTIVES To assess the frequency and mechanisms of xerostomia during PegIFN/Rbv therapy. PATIENTS AND METHODS Thirty-one naïve patients with chronic hepatitis C consecutively received PegIFN-α2a (180 μg/week) plus Rbv (800-1200 mg/day). The controls ...

UNLABELLED Up to 50% of patients with chronic hepatitis C fail to respond to initial therapy with pegylated interferon (PEG-IFN) and ribavirin (RBV). With unsuccessful viral eradication, these patients remain at risk for developing progression of their liver disease. Retreatment with PEG-IFN/RBV yields sustained virologic response (SVR) rates that are under 10%. A wholly synthetic interferon, i...

Background. The recommended therapy for patients with chronic hepatitis C (CHC), genotype 1, who have cirrhosis and have failed prior therapy is 12 weeks of sofosbuvir (SOF), ledipasvir (LDV), and ribavirin (RBV). This recommendation is based on expert opinion, and the efficacy of 12 weeks of SOF/LDV compared to SOF/LDV/RBV in this patient population has not yet been established. Methods. We co...

PURPOSE Although chronic hepatitis C virus (HCV) infection has been treated with the combination of interferon alpha (IFN-α) and ribavirin (RBV) for over a decade, the mechanism of antiviral synergy is not well understood. We aimed to determine the synergistic antiviral mechanisms of IFN-α and RBV combination treatment using HCV cell culture. METHODS The antiviral efficacy of IFN-α, RBV alone...

Based on a sample of 461 micro- and small family businesses in Western Austria, this study aimed to analyze the degree internationalization individual activities value chain their influence export probability firms. The results show that exporting non-exporting are internationalized different can partly explain probability. resource-based view (RBV) only be used limited extent firms, certain fi...

This chapter presents an introvert perspective of strategy formation, through the presentation of the resourcebased view (RBV) concept. We offer a review of a) relevant fundamentals of the strategic management field (the definition of strategy, resources and capabilities), and b) a strategy framework, which incorporates the conceptual knowledge of the RBV intertwined with some well-known tools ...

Based on the resource-based view (RBV) and value cocreation theories, this study investigated how supplier cocreation, intracompany customer influence corporate social responsibility (CSR) innovation economic performance. We collected data from 200 manufacturers to test proposed relationships. The results showed that had different positive impacts CSR; greatest impact, followed by cocreation. C...

We aimed to examine the relationship between renal dysfunction and anaemia that may develop during combination therapy involving pegylated interferon, ribavirin and telaprevir (PEG-IFN/RBV/TVR) for the treatment of chronic hepatitis C. Sixty-eight patients with genotype 1b high viral loads were treated with PEG-IFN/RBV/TVR. Peg-IFN and RBV doses were administered according to body weight. TVR w...

The Resource-Based View (RBV) of marketing strategy development offers a useful method of identifying the distinctive strategic resources that will deliver competitive advantage. In this paper, its applicability to election campaigning is considered for the first time, using evidence from UK political election campaigning. The notion that electoral success is based primarily on the resources de...