BACKGROUND Corus CAD is a clinically validated test based on age, sex, and expression levels of 23 genes in whole blood that provides a score (1-40 points) proportional to the likelihood of obstructive coronary disease. Clinical laboratory process variability was examined using whole blood controls across a 24 month period: Intra-batch variability was assessed using sample replicates; inter-bat...

A batch processing machine can simultaneously process several jobs forming a batch. This paper considers the problem of scheduling jobs with non-identical capacity requirements, on a single-batch processing machine of a given capacity, to minimize the makespan. The processing time of a batch is equal to the largest processing time of any job in the batch. We present some dominance properties fo...

A high yielding, batch mode synthesis of diaryl ethers and sulfides by an S(N)Ar fluoride-mediated process in scCO(2) has been developed; the use of a polymer-supported imidazolium fluoride reagent in batch mode led to the development of a fixed-bed continuous flow process, with high conversions.

Batch chemical manufacturers face several challenges today, including reducing time-to-market, lowering costs, complying with growing regulatory requirements, minimizing waste and emissions and ultimately, increasing return-on-investment. Rapid, effective and informed process development is key to achieving these goals. An advanced modeling and simulation tool, such as BATCH PLUS, can help mana...

BACKGROUND Enzymatic hydrolysis, the rate limiting step in the process development for biofuel, is always hampered by its low sugar concentration. High solid enzymatic saccharification could solve this problem but has several other drawbacks such as low rate of reaction. In the present study we have attempted to enhance the concentration of sugars in enzymatic hydrolysate of delignified Prosopi...

In this paper, we study the effect of batch sizes on performance of flexible manufacturing cells, where performance is evaluated in terms of flow-related measures such as part flow times, work-in-process levels, machine utilizations, and production rates. We introduce new analytical models that account for material handling, both discrete and continuous, and differentiate between process and tr...

There are relatively few industrial applications of process systems to the specialty batch process industry (as compared to bulk continuous or even bulk batch process industry). However, inherent flexibility of these processes can be exploited to increase productivity and product quality. This study is based on a real industrial example of fed-batch polymerisation of ethylene oxide with a base ...

Batch distillation is an important separation process for small-scale production especially in pharmaceutical, specialty chemical and biochemical industries. Although batch distillation units require lower capital cost than continuous units, the unsteady state nature of the process, results in higher operating costs. Optimal control in batch distillation is a mode of operation which allows us t...

Multiway principal component analysis (MPCA) for the analysis and monitoring of batch processes has recently been proposed. Although MPCA has found wide applications in batch process monitoring, it assumes that future batches behave in the same way as those used for model identification. In this study, a new monitoring algorithm, adaptive multiblock MPCA, is developed. The method overcomes the ...