Bad, an inducer of programmed cell death, was recently isolated from a mouse cDNA library by its ability to bind to the anti-apoptotic protein BCL-2. Sequence analysis suggested that Bad was a member of the BCL-2 gene family that encodes both inducers and inhibitors of programmed cell death. To further analyze the role of BAD in the network of homo- and heterodimers formed by the BCL-2 family, ...

Overexpression of the proto-oncogene bcl-2 promotes abnormal cell survival by inhibiting apoptosis. Expression of bcl-2 is determined, in part, by regulatory mechanisms that control the stability of bcl-2 mRNA. Elements in the 3'-untranslated region of bcl-2 mRNA have been shown to play a role in regulating the stability of the message. Previously, it was found that the RNA binding proteins nuc...

The bcl-x gene appears to play a critical role in regulating apoptosis in the developing and mature CNS and following CNS injury. Two isoforms of Bcl-x are produced as a result of alternative pre-mRNA splicing: Bcl-x(L) (the long form) is anti-apoptotic, while Bcl-x(S) (short form) is pro-apoptotic. Despite the antagonistic activities of these two isoforms, little is known about how regulation ...

The proteins of the B-cell lymphoma 2 (Bcl-2) family are important regulators of apoptosis under normal and pathological conditions. Chemical compounds that block the antiapoptotic proteins of this family have been introduced, such as 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide (A...

The bcl-x gene appears to play a critical role in regulating apoptosis in the developing and mature CNS and following CNS injury. Two isoforms of Bcl-x are produced as a result of alternative pre-mRNA splicing: Bcl-xL (the long form) is anti-apoptotic, while Bcl-xS (short form) is pro-apoptotic. Despite the antagonistic activities of these two isoforms, little is known about how regulation of a...

Background: Today, diabetes is considered one of the main causes death so that aim this study was to investigate effect interval training with resveratrol on some apoptotic indices hepatocyte tissue in diabetic male rats. Materials and Methods: In experimental trial, 42 rats were randomly divided into 6 groups, including saline, diabetic, healthy, supplement, exercise, supplementation+interval ...

Abstract: Introduction: Traumatic Brain Injury (TBI) conditions require immediate treatment such as the administration of analgesics and sedation, including remifentanil. TBI will affect levels several inflammatory apoptotic proteins MAC, Bax, Bcl-2. Remifentanil with its high affinity to μ-receptors is thought these has neuroprotective properties prevent secondary brain injury. Objectives: Thi...

In this study, cell death regulation and induction in AML line from a relapsed MLL-rearranged model (MOLM-13) was investigated with doxorubin (Dox) betulinic acid (BetA), singly combination. CyQUANT Direct® Annexin V/propidium iodide double staining were used to measure the cytotoxic effects of compounds, respectively. Reactive oxygen species (ROS) generation measured using 2′,7′-dichlorofluore...

Abstract Diffuse Intrinsic Pontine Glioma (DIPG) is a pediatric brain tumor characterized by epigenetic dysregulation with median survival of 9-11 months. Currently, radiation the only therapy option, and therefore calls for new, effective treatment method. RG2833 penetrant, selective HDAC 1/3 inhibitor. Western blot confirmed that alone downregulates NFkB pathway in multiple DIPG cell lines. W...