OBJECTIVES To develop evidence-based European League Against Rheumatism (EULAR) recommendations for the management of Behçet disease (BD) supplemented where necessary by expert opinion. METHODS The multidisciplinary expert committee, a task force of the EULAR Standing Committee for Clinical Affairs (ESCCA), consisted of nine rheumatologists (one who was also a clinical epidemiologist and one ...

OBJECTIVES Behcet's disease (BD) is a chronic inflammatory disease characterized by recurrent oral and genital ulcerations and ocular lesions. This multisystemic disorder primarily affects the vascular system. In the present study, we aimed to evaluate vascular endothelial function in patients with Behcet' s disease without vascular involvement. STUDY DESIGN We studied 40 patients with BD (44...

BD is a systemic inflammatory disease with a variable vasculitis. Paediatric onset is very rare and carries a strong genetic component. Oral ulcers and fever of unknown origin are frequent at onset and difficult to distinguish from other inflammatory disorders; therefore, expert opinion is still mandatory to recognize the disease early. An international expert consensus has recently proposed ne...

Rheumatoid arthritis is chronic multisystem disease, failure rate with monotherapy is high. The present study was designed to compare the efficacy and safety of triple combination of Methotrexate + Hydroxychloroquine + Sulfasalazine and double combination of Methotrexate + Hydroxychloroquine in patients suffering from Rheumatoid Arthritis. The present study was a prospective, randomized, single...

TNF-α is a pleiotropic cytokine, which plays a major role in the pathogenesis of numerous autoimmune and/or inflammatory systemic diseases. Systemic vasculitis constitutes a group of rare diseases, characterized by inflammation of the arterial or venous vessel wall, causing stenosis and thrombosis. Treatment of the different type of vasculitis mainly relies on steroids and immunosuppressive dru...

Elif Kazancı1, Hüseyin Gülen2, Ayşe Erbay3, Canan Vergin4 1Clinics of Pediatric Hematology Oncology, Dr. Behçet Uz Children’s Hospital, İzmir, Turkey 2Department of Pediatric Hematology, Faculty of Pediatric, Celal Bayar University, Manisa, Turkey 3Clinics of Pediatric Hematology Oncology, Dr. Behçet Uz Children’s Hospital, İzmir, Turkey 4Clinics of Pediatric Hematology Oncology, Dr. Behçet Uz ...

PURPOSE Changes in concentrations of acute phase proteins in the serum of patients might be significant in the pathogenesis of Behçet disease. This report investigates the association between ocular disease activity and serum haptoglobin levels in patients with Behçet disease, and summarizes the current understanding of the correlation between acute phase proteins and Behçet disease based on bo...

OBJECTIVE To compare the pediatric and adult ovarian torsion and explore a quantitative value to predict a possible underlying tumor. METHODS This study included 32 pediatric and 33 adult female cases diagnosed with ovarian torsion and underwent surgical treatment in Dr. Behcet Uz Children's Research Hospital and Ataturk Education and Research Hospital, Izmir, Turkey between 1989 and 2005. We...

AIM To assess the level of caregiving burden and psychological distress among spouses of bipolar disorder - BD (type I and II) patients. METHODS 77 subjects (41 women and 36 men) were enrolled in the study - 44 spouses of bipolar I (BD I) patients and 33 spouses of bipolar II (BD II). The whole group was divided into 4 subgroups: (I) the wives of BD I patients: n=27, (II) the husbands of BD I...