Although DNA is often bent in vivo, it is unclear how DNA-bending forces modulate DNAprotein binding affinity. Here, we report how a range of DNA-bending forces modulates the binding of the Integration Host Factor (IHF) protein to various DNAs. Using solution fluorimetry and electrophoretic mobility shift assays, we measured the affinity of IHF for DNAs with different bending forces and sequenc...

Using a combination of explicit solvent atomistic simulation and continuum theory, here we study the lateral deformation mechanics of three distinct protein structures: an amyloid fibril, a beta helix, and an alpha helix. We find that the two β-sheet rich structures - amyloid fibril and beta helix, with persistence lengths on the order of μm - are well described by continuum mechanical theory, ...

generally an important part of changes in architectural constructions are represented by convertible structures. these kinds of structures are composed typically of hard or soft materials or combination of both, which avoid independent structural deformations and need additional elements such as hinges, rollers or other similar components. development of new construction materials like fiber-re...

[1] Oceanic lithosphere undergoes permanent deformation during subduction once the stresses exceed the elastic limit. Departures from elastic behavior occur by brittle failure in the shallow lithosphere and by a combination of lowand high-temperature creep at greater depths. We combine laboratory-based rheological models with estimates of slab shape from earthquake hypocenters to quantify the b...

AIM The purpose of this study was to establish a general mathematical model for describing the mechanical behaviour of root canal instruments by combining a theoretical analytical approach with a numerical finite-element method. METHOD Mathematical formulas representing the longitudinal (taper, helical angle and pitch) and cross-sectional configurations and area, the bending and torsional ine...

Soft robotic systems generally require both soft actuators and soft sensors to perform complex functions. Separate actuators and sensors are often combined into one composite device when proprioception (self-sensing) is required. In this article, we introduce the concept of using a conductive liquid to perform both the sensing and actuation functions of a proprioceptive soft actuator. The worki...

The mechanical properties of free-standing electron beam deposited amorphous carbon structures have been studied using atomic force microscopy. The fabricated carbon blades are found to be extraordinarily flexible, capable of undergoing vertical deflection up to ∼ 75% of their total length without inelastic deformation. The elastic bending modulus of these structures was calculated to be 28 ± 1...

The existence of distributional solutions is investigated for the time-dependent bending of a plate with transverse shear deformation under mixed boundary conditions. The problem is then reduced to nonstationary boundary integral equations and the existence and uniqueness of solutions to the latter are studied in appropriate Sobolev spaces. 2000 Mathematics Subject Classification: 74H20, 74K20,...

In this paper we present a geometric smoothing technique for three-dimensional surfaces and images. The technique relies on curvature-dependent deformations of surfaces and the intuition that highly curved regions should move into their convexity by an amount proportional to their curvature. While this intuition in 2D has lead to a well-de ned process and formal theorems about its smoothing pro...

This dissertation presents a new development of the wave method for structural health monitoring (SHM) of buildings. Robust and reliable SHM methods help save lives and reduce economic losses caused by earthquakes and other extreme events. Previously, in system identification and health monitoring, it was assumed that waves of different frequency propagate with constant velocity and the identif...