Background and objectivesNumerous clinical studies over recent years have reported an inverse relationship between benign prostatic hyperplasia (BPH) size the incidence of prostate cancer (PCa), leading to hypothesis that expanding BPH zone damages glandular tissue where PCa predominately develops. This systematic review aims establish a historical basis reference on zonal origin (PCa) within p...

1H magnetic resonance spectroscopy studies (360 MHz) were performed on specimens of benign (n = 66) and malignant (n = 21) human prostate tissue from 50 patients, and the spectral data were subjected to multivariate analysis, specifically linear-discriminant analysis. On the basis of histopathological assessments, an overall classification accuracy of 96.6% was achieved, with a sensitivity of 1...

The effects of human primary prostatic stromal cells on the migration and morphogenesis of human prostatic epithelial cells, derived from tumor or benign prostatic hyperplasia tissue, were studied using a three-dimensional coculture system. Epithelial cells from tumor or benign tissue migrated efficiently into collagen gels populated with stromal cells from benign tissue. Only epithelial cells ...

Benign prostatic hyperplasia and prostate cancer remain the most prevalent urologic health concerns affecting elderly men in their lifetime. Only 20% of benign prostatic hyperplasia and prostate cancer cases coexist in the same zone of the prostate and require a long time for initiation and progression. While the pathogenesis of both diseases is not fully understood, benign prostatic hyperplasi...

background phytotherapy is a popular treatment option in cases of benign prostatic hyperplasia (bph), with many different herbal products being used for the treatment of this condition. withania coagulans (wc) is an herbal medicine that has shown anti-tumoral, anti-inflammatory, and antioxidant effects. objectives this study examined the effect of withania coagulans extract (wce) on prostatic c...