نتایج جستجو برای: benzo indeno quinolineone

تعداد نتایج: 8140  

2006
Herman Autrup Roland C. Grafstrom Michele Brugh John F. Lechner Aage Haugen Benjamin F. Trump Curtis C. Harris

The metabolism of benzo(a)pyrene has been investigated in cultured normal human bronchus, colon, duodenum, and esophagus obtained from the same patient. The highest total metabolism was found in bronchus and duodenum, while the highest mean binding level was observed in the bronchus followed, in order, by the esophagus, duodenum, and trans verse colon. A 30-fold interindividual variation in the...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2001
M O James Z Tong L Rowland-Faux C S Venugopal K M Kleinow

The intestinal bioavailability and biotransformation of 3-hydroxybenzo(a)pyrene, a major metabolite of benzo(a)pyrene in many animal species, was investigated in an in situ isolated intestinal preparation from the channel catfish, and in vitro with preparations of catfish intestine and blood. 3-Hydroxybenzo(a)pyrene was a good substrate for adenosine 3'-phosphate 5'-phosphosulfate (PAPS)-sulfot...

Journal: :Cancer research 1977
P G Wislocki R L Chang A W Wood W Levin H Yagi O Hernandez H D Mah P M Dansette D M Jerina A H Conney

SUMMARY Benzo(a)pyrene and five isomenic phenols of benzo (a)pynene were tested for carcinogenicity by the topical application of 0.4 @moIe of each compound to the backs of C57BL/6J mice once every 2 weeks for 60 weeks. 1-, 3-, and 12-hydroxybenzo(a)pyrene were noncarcinogenic , 11-hy droxybenzo(a)pyrene was weakly carcinogenic, and 2-hy droxybenzo(a)pyrene and benzo(a)pyrene were highly car ci...

2014
Rajwant Kaur

Diverse contaminants released into the environment through progress of urbanization and industrialization adversely affect human health. Among various sources of contaminants, especially, in big cities, automobiles play a significant role in aggravating the pollution. Various pollutants viz., heavy metals (Pb, Mn, Ni, Zn, As, Hg, Cd) and Polyaromatic hydrocarbons (Benzo-apyrene, fluoranthene, p...

2014
Yibiao Li Liang Cheng Xiaohang Liu Bin Li Ning Sun

An efficient copper-promoted hydration reaction and its application in the synthesis of benzo[b]furan and benzo[b]thiophene derivatives is presented starting from readily available 2-fluorophenylacetylene derivatives. The key annulation step involves the hydration of the C-F bond of 2-fluorophenylacetylene derivatives followed by an intramolecular annulation to afford benzo[b]furan and benzo[b]...

Journal: :Medicinal Chemistry Research 2022

The inability to meet the desired outcomes of anticancer treatment and decrease in success bacterial fungal infections accelerated research these areas. Our group has conducted numerous studies, especially on benzimidazole ring systems’ antiproliferative antimicrobial activities. In this study, activity compounds was tested against A549, A498, HeLa, A375, HepG2 cancer cell lines by MTT assay. A...

2016
Kuppan Chandralekha Adukamparai Rajukrishnan Sureshbabu Deivasigamani Gavaskar Srinivasakannan Lakshmi

In the title compound, C35H30N4O3, the spiro C atom connects the five-membered pyrrolidine ring and the indeno-quinoxaline ring system. The pyrrolidine ring adopts a twist conformation. An intra-molecular N-H⋯N inter-action between the amino group and the pyrazine ring is observed. In the crystal, mol-ecules are linked by a pairs of C-H⋯O hydrogen bonds, forming inversion dimers.

Journal: :Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2005
Kumiko Ando Eriko Tsuji Yuko Ando Jun-ichi Kunitomo Reina Kobayashi Takehiko Yokomizo Takao Shimizu Masayuki Yamashita Shunsaku Ohta Takeshi Nabe Shigekatsu Kohno Yoshitaka Ohishi

Variable benzo[b]furan derivatives having (E)- and (Z)-2-alkylcarbamoyl-1-methylvinyl groups at the 2-, 4- and 5-positions and a carboxylpropoxy or (1-phenyl)ethoxy group at the 7-position were prepared to find novel and selective leukotriene B4(LTB4) receptor antagonists. (E)-2-(2-diethylcarbamoyl-1-methylvinyl)-7-(1-phenylethoxy)benzo[b]furan (4v) showed selective inhibition to the human BLT2...

2015
Qiulan Wang Yongjie Xue

BACKGROUND To assess the effects of single polycyclic aromatic hydrocarbons (PAHs) on solid tumor initiation, and investigate their roles in immune response regulation. MATERIAL AND METHODS Mice (100) were randomly divided into 5 groups (n=20) to be intraperitoneally injected with 10 daily doses of DMSO (control), anthracene (50 mg/kg), benzo-(a)-pyrene (10 mg/kg), benzo-(a)-pyrene (20 mg/kg)...

Journal: :The Journal of Cell Biology 1985
A L Plant D M Benson L C Smith

Uptake of benzo(a)pyrene by living cultured cells has been visualized in real time using digital fluorescence-imaging microscopy. Benzo(a)pyrene was noncovalently associated with lipoproteins, as a physiologic mode of presentation of the carcinogen to cells. When incubated with either human fibroblasts or murine P388D1 macrophages, benzo(a)pyrene uptake occurred in the absence of endocytosis, w...

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