BACKGROUND Patients with severe mental illness often suffer from disruptions in circadian rest-activity cycles, which might partly be attributed to ongoing psychopharmacological medication. Benzodiazepines are frequently prescribed for prolonged periods despite recommendations of only short-term usage. Melatonin, a naturally occurring nocturnal hormone, has the potential to stabilize disrupted ...

Chronic benzodiazepine treatment can produce tolerance and changes in g-aminobutyric acid (GABA)A receptors. To study the effect of treatment on a selected population of receptors, assays were performed using [H]RY-80, which is selective for GABAA receptors with an a5 subunit. Rats were given a flurazepam treatment known to produce tolerance and down-regulation of benzodiazepine binding, or a d...

black henbane (bh) or hyoscyamus niger, has been used as a medicine since last centuries and has been described in all traditional medicines. it applies as a herbal medicine, but may induce intoxication accidentally or intentionally. all part of bh including leaves, seeds and roots contain some alkaloids such as hyoscyamine, atropine, tropane and scopolamine. bh has pharmacological effects like...

Benzodiazepines derivatives are nitrogen heterocyclic compounds that have various industrial, synthetic, and medicinal applications. Therefore, its potential fully justifies every effort towards the improvement of new, selective, competent production these compounds. The novelty this study encompasses synthesis new hydroxylated analogs 1,5-benzodiazepine together with evaluation their biologica...