the o-nitrophenyl group at position 4 of dihydropyridine of nifedipine analogues was replaced with 2-alkylthio-1-benzyl-5-imidazolyl substituent. starting from dihydroxyacetone 2-alkythio-1-benzyl- 5-formyl imidazole (3) was first synthesized which was subsequently used in synthesizing symmetrical (5a-f) and asymmetrical (6a,b) dihydropyridines. primarily pharmacological studies of the title co...

Ezlopitant is metabolized by cytochrome P450 primarily to two metabolites: a benzyl alcohol and a corresponding alkene. The alkene arises as a direct product of metabolism of ezlopitant rather than through dehydration of the benzyl alcohol. The mechanism of this cytochrome P450 (P450)-catalyzed dehydrogenation reaction was probed with five different deuterium-labeled analogs of ezlopitant. At s...

Ethylene is a gaseous plant hormone involved in many physiological processes including senescence, fruit ripening, and defence. Here the effects of pollination and wound-induced ethylene signals on transcript accumulation of benzoyl CoA:benzyl alcohol/phenylethanol benzoyltransferase (PhBPBT) are shown in Petuniaxhybrida cv. Mitchell 'Diploid' (MD). In petunia, PhBPBT is responsible for the bio...

Maca (Lepidium meyenii) has been used as a food in Peru for thousands of years. More recently a wide array of commercial maca products have gained popularity as dietary supplements, with claims of anabolic and aphrodisiac effects, although the biologically active principles are not fully known. In an earlier chemical investigation, two new alkamides and a novel fatty acid, as well as the N-hydr...

Some time ago we demonstrated the acetylation of S-benzyl-L-cysteine in the dog, rabbit, rat, and man (l-3). Administration of S-benzyl-ncysteine to rats (4, 5) or man (3) was followed by the excretion of some N-acetyl-S-benzyl-L-cysteine, thus indicating a partial inversion of the D derivative of cysteine to the optical antipode. Ample experimental evidence is available to show that oxidative ...

Whole-cell and cell-extract experiments were performed to study the mechanism of oxalate metabolism in the acetogenic bacterium Moorella thermoacetica. In short-term, whole-cell assays, oxalate consumption was low unless cell suspensions were supplemented with CO(2), KNO(3), or Na(2)S(2)O(3). Cell extracts catalyzed the oxalate-dependent reduction of benzyl viologen. Oxalate consumption occurre...

New resveratrol (trans-3,4',5-trihydroxystilbene) analogs were synthesized and screened for their in vitro cancer chemopreventive potential using various bioassays relevant for the prevention of carcinogenesis in humans: two assays to detect modulators of carcinogen metabolism (Cyp1A inhibition; determination of NAD(P)H/quinone reductase (QR) activity), three assays to identify radical scavengi...

Two imidazolium cations containing a benzyl group, 1-benzyl-3-methylimidazolium and 1-benzyl-2,3-dimethylimidazolium, generally produce the large pore zeolite MTW when used as structure directing agents in the synthesis of pure silica zeolites by the fluoride route. When working at low water contents only the smallest of these cations is able to crystallize MFI, a zeolite with crossing medium p...

A series of bis(amidinate) tin(II) complexes is synthesized and shown to rapidly polymerize ε-caprolactone (ε-CL) in the presence and absence of benzyl alcohol giving high-molecular-weight poly(ε-CL) (M(n) up to 160,600 Da). Ligands having electron donating groups were found to accelerate the polymerization by making the complex more nucleophilic.

The Sn(IV) atom in the title compound, [Sn(C(6)H(5))(2)Cl(2)(C(13)H(12)OS)], displays a distorted C(2)Cl(2)O trigonal-bipyramidal coordination environment, with a mean Sn-C distance of 2.121 (9) Å and with Sn-O = 2.331 (2) Å. The Sn(IV) atom is displaced by 0.169 (2) Å from the equatorial C(2)Cl plane towards the direction of the second axially bonded Cl atom.