Glucocorticoids appear to play an integral role in stimulating surfactant synthesis by activating the rate-regulatory enzyme for phosphatidylcholine synthesis, CTP:cholinephosphate cytidylyltransferase (CT). The activity of liver CT, in vitro, has been shown to be inhibited by the sphingomyelin hydrolysis product, sphingosine. In order to investigate the mechanisms by which glucocorticoids alte...

OBJECTIVE Antimicrobial agents in combination with anti-inflammatory drugs have been usually prescribed in both Medicine and Dentistry. However, few scientific reports support this clinical practice. The aim of this study was to evaluate the effect of betamethasone and diclofenac sodium on serum and tissue concentration of amoxicillin in rats. METHODS Four polyurethane sponges were implanted ...

Background Psoriasis is a common chronic inflammatory skin disease characterized by erythematous and scaling plaques. The ongoing understanding of its pathogenesis has led to new therapeutic options and new areas of research which aimed at reducing keratinocyte proliferation and suppressing T-cell activation. Objectives To evaluate the efficacy and safety of topical use of a combined formulatio...

Background Psoriasis is a common chronic inflammatory skin disease characterized by erythematous and scaling plaques. The ongoing understanding of its pathogenesis has led to new therapeutic options and new areas of research which aimed at reducing keratinocyte proliferation and suppressing T-cell activation. Objectives To evaluate the efficacy and safety of topical use of a combined formulatio...

background: low-level laser therapy (lllt) has shown a promising effect in ameliorating symptoms of rheumatoid arthritis (ra). the aim of this investigation was to compare the early and late antiinfl ammatory effects of lllt and betamethasone in ra. materials and methods: in this animal experimental study, after inducing a model of ra in temporomandibular joint (tmj) of 37 wistar rats using adj...

BACKGROUND AND PURPOSE Exhaled nitric oxide (eNO), a non-invasive marker that reflects the degree of airway inflammation, may be useful for assessing the response to anti-inflammatory treatment of asthma. The purpose of this randomized prospective study was to compare the effect of a nebulized terbutaline plus a single intravenous dose of betamethasone at baseline followed by a second of terbut...

Fetal exposure to synthetic glucocorticoids in sheep results in increased fetal hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) and corticosteroid-binding globulin (CBG) protein levels and insulin resistance in postnatal life. The aim was to determine whether these changes persisted to adulthood and whether alterations in mediators of hepatic glucocorticoid and glucose regulati...

Psoriasis is a chronic inflammatory skin disease mediated by dysregulated auto-reactive immune system. In this study, in order to confirm and further extend the pharmacological basis of topical steroids in psoriasis therapy, we investigated the effect of betamethasone ointment on imiquimod (IMQ)-induced skin inflammation in mice. In BALB/c mice, topical IMQ at the dose of 250 µg each on both si...